Featured Publications
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking J, Xie Q, Nathan C. NITRIC OXIDE AND MACROPHAGE FUNCTION. Annual Review Of Immunology 1997, 15: 323-350. PMID: 9143691, DOI: 10.1146/annurev.immunol.15.1.323.ChaptersMeSH KeywordsAnimalsAnti-Bacterial AgentsCalmodulinGene Expression Regulation, EnzymologicHomeostasisHumansImmunosuppression TherapyMacrophagesMiceNeoplasms, ExperimentalNitric OxideNitric Oxide SynthaseRatsConceptsExpression of NOS2Nitric oxide synthaseAdaptive immune systemNormal host cellsRemarkable molecular machinesInflammatory diseasesLymphocyte proliferationNO pathwayOxide synthaseImmune responseMacrophage productsMacrophage functionSuppressive effectImmune systemNOS2Nitric oxideHigh-output isoformTumor cellsMacrophagesCytotoxic actionElevated Ca2Transcriptional inductionFunctional dimerCytotoxic activityMolecular machines
2019
Cell-autonomous immunity by IFN-induced GBPs in animals and plants
Huang S, Meng Q, Maminska A, MacMicking JD. Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Current Opinion In Immunology 2019, 60: 71-80. PMID: 31176142, PMCID: PMC6800610, DOI: 10.1016/j.coi.2019.04.017.Peer-Reviewed Original ResearchConceptsGuanylate binding proteinsHost cell interiorCell-autonomous immunitySensory hubMammalian cytosolAnimal kingdomDownstream effectorsDirect bactericidal activityHost cellsBinding proteinCell interiorBacterial pathogensPlantsRecruitment platformDefensive repertoireArabidopsisOrthologuesGTPasesPhytopathogensBacterial colonizationMicrobesCytosolEffectorsProteinColonization