Interferon-inducible effector mechanisms in cell-autonomous immunity
MacMicking JD. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nature Reviews Immunology 2012, 12: 367-382. PMID: 22531325, PMCID: PMC4150610, DOI: 10.1038/nri3210.Peer-Reviewed Original ResearchConceptsCell-autonomous immunityIndividual host cellsHigher organismsVertebrate cellsEffector proteinsIFN-inducible proteinsAutophagic machineryViral life cycleNew proteinsIntracellular distancesGene programMicrobial replicationCapsid assemblyEssential amino acidsMicrobial pathogensHost cellsIntracellular bacteriaIndividual bacteriaKey PointsAtInnate immune systemAmino acidsInterferon familyVariety of mechanismsProteinPathogen classes