Featured Publications
Interferon-inducible effector mechanisms in cell-autonomous immunity
MacMicking JD. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nature Reviews Immunology 2012, 12: 367-382. PMID: 22531325, PMCID: PMC4150610, DOI: 10.1038/nri3210.Peer-Reviewed Original ResearchConceptsCell-autonomous immunityIndividual host cellsHigher organismsVertebrate cellsEffector proteinsIFN-inducible proteinsAutophagic machineryViral life cycleNew proteinsIntracellular distancesGene programMicrobial replicationCapsid assemblyEssential amino acidsMicrobial pathogensHost cellsIntracellular bacteriaIndividual bacteriaKey PointsAtInnate immune systemAmino acidsInterferon familyVariety of mechanismsProteinPathogen classes
2019
Cell-autonomous immunity by IFN-induced GBPs in animals and plants
Huang S, Meng Q, Maminska A, MacMicking JD. Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Current Opinion In Immunology 2019, 60: 71-80. PMID: 31176142, PMCID: PMC6800610, DOI: 10.1016/j.coi.2019.04.017.Peer-Reviewed Original ResearchConceptsGuanylate binding proteinsHost cell interiorCell-autonomous immunitySensory hubMammalian cytosolAnimal kingdomDownstream effectorsDirect bactericidal activityHost cellsBinding proteinCell interiorBacterial pathogensPlantsRecruitment platformDefensive repertoireArabidopsisOrthologuesGTPasesPhytopathogensBacterial colonizationMicrobesCytosolEffectorsProteinColonization