Featured Publications
Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Karupiah G, Xie Q, Buller R, Nathan C, Duarte C, MacMicking J. Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase. Science 1993, 261: 1445-1448. PMID: 7690156, DOI: 10.1126/science.7690156.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid OxidoreductasesAnimalsArginineCell LineCells, CulturedEctromelia virusEctromelia, InfectiousEnzyme InductionFemaleHumansInterferon-gammaMacrophagesMiceMice, Inbred C57BLNitric OxideNitric Oxide SynthaseOmega-N-MethylarginineSimplexvirusTransfectionVaccinia virusVirus ReplicationConceptsViral replicationIFN-gammaHerpes simplex-1 virusNitric oxideDetectable NO synthesisSubstantial antiviral effectEctromelia virus infectionNitric oxide synthaseInducible NO synthaseIFN-gamma-treated macrophagesOxide synthaseAntiviral effectVirus infectionNO synthaseNO synthesisAntiviral activityInterferonEpithelial cellsMouse macrophagesCell productionMacrophagesCell typesSynthaseInhibitors
1998
Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection
Karupiah G, Chen J, Nathan C, Mahalingam S, MacMicking J. Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection. Journal Of Virology 1998, 72: 7703-7706. PMID: 9696880, PMCID: PMC110049, DOI: 10.1128/jvi.72.9.7703-7706.1998.Peer-Reviewed Original ResearchConceptsNitric oxide synthase 2NOS2-/- miceEctromelia virusCytotoxic T lymphocyte activityEctromelia virus infectionGamma interferon secretionT lymphocyte activityAcute viral infectionSynthase 2Lymphocyte activityNK cellsInterferon secretionVirus infectionImmune responseMonogenic determinantsViral infectionHost survivalCausative agentInfectionMousepoxSecretion