Featured Publications
IFN-Inducible GTPases in Host Cell Defense
Kim BH, Shenoy AR, Kumar P, Bradfield CJ, MacMicking JD. IFN-Inducible GTPases in Host Cell Defense. Cell Host & Microbe 2012, 12: 432-444. PMID: 23084913, PMCID: PMC3490204, DOI: 10.1016/j.chom.2012.09.007.Peer-Reviewed Original ResearchConceptsGuanylate binding proteinsIFN-inducible GTPasesHuman genome-wide association studiesProtein complex assemblyGenome-wide association studiesPathogen-containing vacuolesHost cell defenseVesicular trafficTranscriptional profilingComplex assemblyCell defenseCell-intrinsic responsesAssociation studiesGTPasesBinding proteinCell interiorIndividual cellsAltered expressionGTPase MDiverse groupCentral roleAutophagicCytosolSpeciesPlants
2019
Cell-autonomous immunity by IFN-induced GBPs in animals and plants
Huang S, Meng Q, Maminska A, MacMicking JD. Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Current Opinion In Immunology 2019, 60: 71-80. PMID: 31176142, PMCID: PMC6800610, DOI: 10.1016/j.coi.2019.04.017.Peer-Reviewed Original ResearchConceptsGuanylate binding proteinsHost cell interiorCell-autonomous immunitySensory hubMammalian cytosolAnimal kingdomDownstream effectorsDirect bactericidal activityHost cellsBinding proteinCell interiorBacterial pathogensPlantsRecruitment platformDefensive repertoireArabidopsisOrthologuesGTPasesPhytopathogensBacterial colonizationMicrobesCytosolEffectorsProteinColonization