2007
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.Peer-Reviewed Original ResearchConceptsMenopausal womenTryptophan depletionSelective serotonin reuptake inhibitor fluoxetineAcute tryptophan depletion paradigmSerotonin reuptake inhibitor fluoxetineTryptophan depletion paradigmPathogenesis of depressionReuptake inhibitor fluoxetineMajor depressive episodeAcute tryptophan depletionRelapse of depressionWorsening of moodWeeks of recoveryActive tryptophan depletionWechsler Memory ScaleAssessment of moodDepressive episodeRisk factorsDepressive relapseMajor depressionSignificant worseningNeuroendocrine functionVerbal memorySerotonergic contributionMemory Scale
2006
Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006, 186: 425. PMID: 16724188, DOI: 10.1007/s00213-006-0313-7.Peer-Reviewed Original ResearchConceptsPostpartum major depressionCortical GABA concentrationsGABA concentrationPostpartum womenOccipital cortex GABA concentrationsOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyFollicular phase femalesGamma-aminobutyric acid concentrationResumption of menstruationFollicular phase womenMonths of deliveryMid-follicular phaseOvarian hormone levelsSubgroup of womenMagnetic resonance spectroscopy studyAllopregnanolone concentrationsPuerperal womenALLO levelsBlood levelsPostpartum periodHealthy controlsMajor depressionGABA levelsHormone levels
2005
Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsOccipital cortex GABA concentrationsGABA levelsProton magnetic resonance spectroscopyImpact of nicotineMenstrual cycleGABA concentrationFemale smokersCortical gamma-aminobutyric acid (GABA) levelsUnderwent proton magnetic resonance spectroscopyGamma-aminobutyric acid (GABA) levelsCentral GABAergic functionCortical GABA concentrationsNicotine-dependent menAmino acid neurotransmissionImpact of smokingPotential risk factorsMenstrual cycle phaseShort-term abstinenceGABAergic functionNicotine modulationSmoking menSmoking cessationFollicular phaseSmoking abstinence
2002
Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study
Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study. JAMA Psychiatry 2002, 59: 851-858. PMID: 12215085, DOI: 10.1001/archpsyc.59.9.851.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderCortical GABA levelsGABA neuronal functionBrain GABA concentrationsHealthy womenMenstrual cycleGABA levelsNeuronal functionNeuroactive steroidsFollicular phaseDysphoric disorderGABA concentrationOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyUniversity-based medical centerHealthy menstruating womenΓ-aminobutyric acid (GABA) levelsMagnetic resonance spectroscopy studyLate luteal phaseMenstrual cycle phaseHealth Research programmeMid lutealNeurosteroid levelsGABAergic systemMenstruating women