N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder
Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology 2005, 184: 254-256. PMID: 16374600, DOI: 10.1007/s00213-005-0246-6.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderObsessive-compulsive disorderN-acetylcysteineGlutamatergic neurotransmissionUse of NACYale-Brown Obsessive Compulsive Scale scoresSerotonin reuptake inhibitorsEfficacy of augmentationRecent clinical reportsTreatment of OCDCompulsive Scale scoresNAC augmentationGlutamatergic dysfunctionReuptake inhibitorsLabel usePsychiatric disordersClinical reportsScale scoreModulating agentsDisordersSingle casePatientsFluvoxamineNeurotransmissionOCD symptoms