Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence
Martinez D, Slifstein M, Gil R, Hwang DR, Huang Y, Perez A, Frankle WG, Laruelle M, Krystal J, Abi-Dargham A. Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence. Biological Psychiatry 2008, 65: 175-180. PMID: 18962444, PMCID: PMC2621104, DOI: 10.1016/j.biopsych.2008.08.034.Peer-Reviewed Original ResearchConceptsType II alcoholismSerotonergic transmissionControl subjectsTransporter levelsAlcohol-dependent subjectsNonspecific partition coefficientEmission Tomography ImagingPositron emission tomography (PET) imagingSeverity of alcoholismDifferent brain regionsTwo-tissue compartment modelSerotonin innervationTransporter availabilityAlcoholic subjectsRodent modelsAlcohol dependenceDisease severitySignificant negative correlationBrain regionsSerotonin transporterSubjects SubjectsAlcoholismTomography imagingSignificant differencesPatients