2024
Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty
Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry 2024, 96: 256-267. PMID: 38316333, PMCID: PMC11269024, DOI: 10.1016/j.biopsych.2024.01.025.Peer-Reviewed Original ResearchPrediction error signalsResponses to conditioned stimuliThreat prediction errorsReinforcement learning modelThreat learningAnticipation of dangerAversive learningMemory strengthConditioned stimulusNoradrenergic signalingDefensive behaviorError signalPrediction errorAuditory stimuliTask structureNorepinephrine releaseNorepinephrineLearning modelsPredictive signalsStimuliFootshockDopamineLearningRewardError
2009
Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas
Corlett PR, Simons JS, Pigott JS, Gardner JM, Murray GK, Krystal JH, Fletcher PC. Illusions and Delusions: Relating Experimentally-Induced False Memories to Anomalous Experiences and Ideas. Frontiers In Behavioral Neuroscience 2009, 3: 53. PMID: 19956402, PMCID: PMC2786301, DOI: 10.3389/neuro.08.053.2009.Peer-Reviewed Original ResearchSalience hypothesisMemory illusionsCognitive underpinningsDeese-RoedigerFalse memoriesPrevious stimuliAnomalous experiencesSalience modelMagical thinkingBelief formationIllusionStimuliUnpredictable experienceTheoretical importanceMemoryPerceptionExperiencePsychosisCognitionFluencySalienceAttributionHypothesisMcDermottFamiliarity
2008
Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission
Watson TD, Petrakis IL, Edgecombe J, Perrino A, Krystal JH, Mathalon DH. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. The International Journal Of Neuropsychopharmacology 2008, 12: 357-370. PMID: 18771605, PMCID: PMC2900256, DOI: 10.1017/s1461145708009334.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceCerebral CortexDouble-Blind MethodElectroencephalographyEvoked PotentialsFemaleGABA ModulatorsHumansKetamineMalePain MeasurementPattern Recognition, VisualPhotic StimulationReaction TimeReceptors, GABA-BReceptors, N-Methyl-D-AspartateStatistics as TopicThiopentalYoung AdultConceptsPlacebo-controlled studyNMDA receptor systemSubanaesthetic dosesGABA neurotransmissionChallenge sessionsDrug effectsNMDA antagonismHealthy adultsNovel stimuliCortical processingReceptor systemPlaceboDrugsCounterbalanced orderKetaminePotential correlatesNeural correlatesP3a amplitudeNovelty processingP300 componentStandard stimuliStimulus processingStimuliTarget stimuliN2 amplitude
2000
The Emerging Neurobiology of Dissociative States
Krystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. Springer Series On Stress And Coping 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.Peer-Reviewed Original ResearchPerceptual alterationsFocusing of attentionCognitive processesDistorts perceptionsPerceptual distortionReduced processingInformation processingPeripheral stimuliProlonged sensory deprivationSensory perceptionSensory deprivationPerceptionEveryday lifeDissociative statesExact transcriptionProcessingDepersonalizationMemoryIllusionNeurobiologyStimuliDerealizationHallucinationsAttentionPeople
1999
Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report
Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.Peer-Reviewed Original ResearchConceptsNormal control subjectsSchizophrenia patientsSensory gatingControl subjectsNormal subjectsSex-matched normal control subjectsPathophysiology of schizophreniaStimulus repetitionStable schizophrenia patientsSchizophrenia subjectsSimilar abnormalitiesPatientsPreliminary reportDysfunctionDegree of attenuationSchizophreniaLate phaseSubjectsDeviant stimuliStimulus changeIrrelevant stimuliPathophysiologyStimuliPotential paradigmAbnormalities
1992
Startle gating deficits occur across prepulse intensities in schizophrenic patients
Grillon C, Ameli R, Charney D, Krystal J, Braff D. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biological Psychiatry 1992, 32: 939-943. PMID: 1467378, DOI: 10.1016/0006-3223(92)90183-z.Peer-Reviewed Original ResearchConceptsPrepulse inhibitionPrepulse stimulusSchizophrenic patientsStartle reflexControl groupStartle gating deficitsCentral inhibitory mechanismsDeficient prepulse inhibitionGating deficitsStartling stimulusNormal controlsPatientsReflexPrepulse intensityInhibitory mechanismFurther studiesStimuliInhibitionGroup