1994
Effects of sleep deprivation on serotonin function in depression
Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.Peer-Reviewed Original ResearchConceptsUndisturbed sleepSleep deprivationPRL riseDepressed patientsSerotonin functionFemale depressed patientsSD-induced changesIntravenous tryptophanAntidepressant treatmentPRL responseDepressed menTRP infusionScore changeMood changesPatientsMood ratingsMenProlactinConsiderable evidenceWomenLow sensitivitySignificant relationshipDeprivationInfusionSleep
1990
Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs.
Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. The Journal Of Clinical Psychiatry 1990, 51 Suppl: 44-50; discussion 51-2. PMID: 2182616.Peer-Reviewed Original ResearchConceptsIntravenous L-tryptophanBrain serotonin functionAntidepressant drug actionRole of serotoninL-tryptophanThymoleptic drugsPlasma TrpView of evidencePRL responseNeuroendocrine effectsSerum prolactinSerotonin functionAntidepressant drugsClinical dataTherapeutic effectPreclinical studiesReceptor sensitivityClinical settingChallenge paradigmDrug actionRecent evidenceAntidepressantsProlactinDrugsDepression
1989
The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey
Krystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.Peer-Reviewed Original ResearchConceptsGrowth hormonePlasma MHPGChair-adapted rhesus monkeysRespiratory rateRhesus monkeysSignificant dose-dependent increaseEffects of inhalationDose-dependent increaseCarbon dioxide inhalationNorepinephrine metabolitePlasma levelsPlasma hormonesMHPGBehavioral activationInhalationHormoneProlactinShort durationCortisolMonkeysMinutesPeak changes