2002
Frontotemporal neural systems in bipolar disorder.
Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars In Clinical Neuropsychiatry 2002, 7: 243-54. PMID: 12382207, DOI: 10.1053/scnp.2002.35220.Peer-Reviewed Original ResearchConceptsBipolar disorderBD symptomsNeural system abnormalitiesRegional brain abnormalitiesLocalization of lesionsAmygdalar abnormalitiesNeural systemsFrontotemporal neural systemBrain abnormalitiesBrain lesionsSystem abnormalitiesManic stateMood symptomsTrait abnormalityUnipolar depressionAbnormalitiesMood changesVivo evidenceSymptomsPotential targetNeuroanatomic modelLesionsDisordersDepressionInvolvement
1994
Effects of sleep deprivation on serotonin function in depression
Salomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.Peer-Reviewed Original ResearchConceptsUndisturbed sleepSleep deprivationPRL riseDepressed patientsSerotonin functionFemale depressed patientsSD-induced changesIntravenous tryptophanAntidepressant treatmentPRL responseDepressed menTRP infusionScore changeMood changesPatientsMood ratingsMenProlactinConsiderable evidenceWomenLow sensitivitySignificant relationshipDeprivationInfusionSleep