Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mapping