1995
Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder
Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. Psychopharmacology 1995, 117: 466-471. PMID: 7604149, DOI: 10.1007/bf02246220.Peer-Reviewed Original ResearchConceptsAcoustic startle reflexRandomized double-blind placebo-controlled designCombat controlsDouble-blind placebo-controlled designAlpha-2 receptor antagonistEffects of yohimbinePlacebo-controlled designHealthy human controlsCombat veteransPost-traumatic stress disorderSevere stress resultsHealthy combat controlsInstantaneous rise timeSaline placeboCardiovascular effectsExcitatory effectsNeuronal reactivityNoradrenergic functionReceptor antagonistClinical studiesAcoustic startleYohimbinePTSD patientsPTSD subjectsNeurochemical basis
1993
Yohimbine — facilitated acoustic startle reflex in humans
Morgan CA, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine — facilitated acoustic startle reflex in humans. Psychopharmacology 1993, 110: 342-346. PMID: 7831429, DOI: 10.1007/bf02251291.Peer-Reviewed Original ResearchConceptsAcoustic startle reflexHealthy subjectsRandomized double-blind placebo-controlled designStartle amplitudeDouble-blind placebo-controlled designStartle reflexAlpha-2 receptor antagonistEffects of yohimbinePlacebo-controlled designDB intensityUseful animal modelHealthy human subjectsInstantaneous rise timeSaline placeboCardiovascular effectsExcitatory effectsNoradrenergic functionReceptor antagonistPlasma MHPGPreclinical studiesPeak anxietyYohimbineNeurochemical basisAnimal modelsRank testing