2019
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, Haswell CC, Averill CL, Baugh LA, Bomyea J, Bruce SE, Cha J, Choi K, Davenport ND, Densmore M, du Plessis S, Forster GL, Frijling JL, Gonenc A, Gruber S, Grupe DW, Guenette JP, Hayes J, Hofmann D, Ipser J, Jovanovic T, Kelly S, Kennis M, Kinzel P, Koch SBJ, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lebois LAM, Li G, Magnotta VA, Manthey A, May GJ, Menefee DS, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O’Doherty D, Peverill M, Ressler KJ, Roos A, Sheridan MA, Sierk A, Simmons A, Simons RM, Simons JS, Stevens J, Suarez-Jimenez B, Sullivan DR, Théberge J, Tran JK, van den Heuvel L, van der Werff SJA, van Rooij SJH, van Zuiden M, Velez C, Verfaellie M, Vermeiren RRJM, Wade BSC, Wager T, Walter H, Winternitz S, Wolff J, York G, Zhu Y, Zhu X, Abdallah CG, Bryant R, Daniels JK, Davidson RJ, Fercho KA, Franz C, Geuze E, Gordon EM, Kaufman ML, Kremen WS, Lagopoulos J, Lanius RA, Lyons MJ, McCauley SR, McGlinchey R, McLaughlin KA, Milberg W, Neria Y, Olff M, Seedat S, Shenton M, Sponheim SR, Stein DJ, Stein MB, Straube T, Tate DF, van der Wee NJA, Veltman DJ, Wang L, Wilde EA, Thompson PM, Kochunov P, Jahanshad N, Morey RA. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Molecular Psychiatry 2019, 26: 4315-4330. PMID: 31857689, PMCID: PMC7302988, DOI: 10.1038/s41380-019-0631-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderWhite matter organizationStress disorderFractional anisotropyWhite matter microstructural organizationCurrent alcohol abuseTraumatic brain injuryChildhood trauma exposureMulti-cohort analysisWhite matter metricsAltered structural connectivityLower fractional anisotropyMatter organizationPsychotropic medicationsComorbid depressionBrain injuryCorpus callosumRight hippocampusAlcohol abuseDiffusion MRINeurobiological vulnerabilityHippocampal networkTrauma exposureAge 18Small sample size
2008
Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study
Jackowski AP, Douglas-Palumberi H, Jackowski M, Win L, Schultz RT, Staib LW, Krystal JH, Kaufman J. Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study. Psychiatry Research 2008, 162: 256-261. PMID: 18296031, PMCID: PMC3771642, DOI: 10.1016/j.pscychresns.2007.08.006.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCorpus callosumStress disorderPathophysiology of PTSDDiffusion tensor imaging studyHistory of traumaWhite matter developmentEffects of stressWhite matter tractsWhite matter integrityDiffusion tensor imagingStudies of adultsInterhemispheric projectionsPediatric studiesPrimary white matter tractPreclinical studiesNormal controlsPosterior corpusHippocampus atrophyImaging studiesBrain structuresTensor imagingFractional anisotropyCallosumChildren