Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration
Rasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.Peer-Reviewed Original ResearchConceptsAcid administrationKynurenic acidSubcutaneous administrationPeripheral excitatory amino acid receptorsExcitatory amino acid antagonist kynurenic acidExcitatory amino acid receptorsAntagonist kynurenic acidExcitatory amino acidsAmino acid receptorsLocus coeruleus neuronsMorphine-dependent ratsBlood-brain barrierSingle-unit recordingsMorphine withdrawalCoeruleus neuronsAntagonist treatmentAbstinence symptomsOpiate withdrawalUnit recordingsAnesthetized animalsAcid receptorsBehavioral signsAdministrationDifferential effectsWithdrawal