2011
Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration
Freeman WM, VanGuilder HD, Guidone E, Krystal JH, Grant KA, Vrana KE. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The International Journal Of Neuropsychopharmacology 2011, 14: 899-911. PMID: 21303580, PMCID: PMC3107900, DOI: 10.1017/s1461145711000046.Peer-Reviewed Original ResearchConceptsSerum amyloid A4Excessive alcohol consumptionNon-human primatesAlcohol consumptionPotential biomarkersInter-alpha inhibitor H4Plasma proteinsAltered plasma levelsPlasma samplesExcessive alcohol useAlcohol use disorderNovel potential biomarkersLevels of fibronectinMonitoring of subjectsRetinol-binding proteinAlcohol intakeChronic alcoholWidespread clinical usagePlasma levelsAmyloid A4Lipoprotein metabolismImmune functionUse disordersSelf-administer high levelsBiomarker panel
2003
Neurobiological Correlates of the Disposition and Maintenance of Alcoholism
Heinz A, Schäfer M, Higley J, Krystal J, Goldman D. Neurobiological Correlates of the Disposition and Maintenance of Alcoholism. Pharmacopsychiatry 2003, 36: 255-258. PMID: 14677088, DOI: 10.1055/s-2003-45139.Peer-Reviewed Original ResearchConceptsAlcohol effectsMaintenance of alcoholismCurrent disease conceptsNeurobiological foundationsDispositional factorsNeurobiological correlatesMotivational therapyConsequences of alcoholismAlcohol cravingReward systemAlcohol intakeClinical withdrawalReduced controlTreatment of alcoholismChronic alcohol effectsNew treatment optionsNeuroadaptationsResearch pointsRelapse riskMonoaminergic dysfunctionPatient groupTreatment optionsGlutamatergic neurotransmissionCentral GABAergicPharmacological approaches