1996
Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis
Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. Journal Of Neuropsychiatry 1996, 8: 60-66. PMID: 8845703, DOI: 10.1176/jnp.8.1.60.Peer-Reviewed Original ResearchConceptsSensory gatingChronic psychotic patientsAcoustic startle reflexLateralized attentionImpaired sensory gatingPosner testSensorimotor gatingPsychotic patientsContinuous Performance TestStartle reflexInformation-processing deficitsDistractibility tasksPreliminary evidenceDistractibilityTask scores
1995
Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder
Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. Psychopharmacology 1995, 117: 466-471. PMID: 7604149, DOI: 10.1007/bf02246220.Peer-Reviewed Original ResearchConceptsAcoustic startle reflexRandomized double-blind placebo-controlled designCombat controlsDouble-blind placebo-controlled designAlpha-2 receptor antagonistEffects of yohimbinePlacebo-controlled designHealthy human controlsCombat veteransPost-traumatic stress disorderSevere stress resultsHealthy combat controlsInstantaneous rise timeSaline placeboCardiovascular effectsExcitatory effectsNeuronal reactivityNoradrenergic functionReceptor antagonistClinical studiesAcoustic startleYohimbinePTSD patientsPTSD subjectsNeurochemical basis
1993
Yohimbine — facilitated acoustic startle reflex in humans
Morgan CA, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine — facilitated acoustic startle reflex in humans. Psychopharmacology 1993, 110: 342-346. PMID: 7831429, DOI: 10.1007/bf02251291.Peer-Reviewed Original ResearchConceptsAcoustic startle reflexHealthy subjectsRandomized double-blind placebo-controlled designStartle amplitudeDouble-blind placebo-controlled designStartle reflexAlpha-2 receptor antagonistEffects of yohimbinePlacebo-controlled designDB intensityUseful animal modelHealthy human subjectsInstantaneous rise timeSaline placeboCardiovascular effectsExcitatory effectsNoradrenergic functionReceptor antagonistPlasma MHPGPreclinical studiesPeak anxietyYohimbineNeurochemical basisAnimal modelsRank testing