2022
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Halasa NB, Spieker AJ, Young CC, Olson SM, Newhams MM, Amarin JZ, Moffitt KL, Nakamura MM, Levy ER, Soma VL, Talj R, Weiss SL, Fitzgerald JC, Mack EH, Maddux AB, Schuster JE, Coates BM, Hall MW, Schwartz SP, Schwarz AJ, Kong M, Spinella PC, Loftis LL, McLaughlin GE, Hobbs CV, Rowan CM, Bembea MM, Nofziger RA, Babbitt CJ, Bowens C, Flori HR, Gertz SJ, Zinter MS, Giuliano JS, Hume JR, Cvijanovich NZ, Singh AR, Crandall HA, Thomas NJ, Cullimore ML, Patel MM, Randolph AG, Kong M, Gaspers M, Typpo K, Sanders R, Katherine I, Peter M, Schwarz A, Babbitt C, Helen H, Cvijanovich N, Zinter M, Maddux A, Osborne C, Sara S, Mourani P, Emily P, Van K, Carroll C, Giuliano J, McLaughlin G, Tarquinio K, Michelson K, Coates B, Rowan C, Wellnitz K, Bhoojhawon, Sullivan J, Montgomery V, Havlin K, Bradford T, Riggs B, Bembea M, Randolph A, Newhams M, Chen S, Young C, Moffitt K, Nakamura M, Carroll R, Yager P, Fernandes N, Flori H, Heidemann S, Hume J, Levy E, Hobbs C, Martin L, Malloch L, Inagaki K, Dhanrajani A, Schuster J, Kietzman A, Hill S, Spinella P, Cullimore M, McCulloh R, Clouser K, Gertz S, Kleinman L, Li S, Horwitz S, Ratner A, Dapul H, Soma V, Keenaghan M, Singh A, Harwayne-Gidansky I, Hymes S, Doymaz S, Schwartz S, Walker T, Hall M, Shein S, Lansell A, Nofziger R, Staat M, Fitzgerald J, Weiss S, Thomas N, Fink E, Carcillo J, Mack E, Smallcomb L, Halasa N, Stewart L, Romero Y, Hayek H, Loftis L, Munoz A, Bowens C, Maamari M, Crandall H, Smith L, McGuire J. Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clinical Infectious Diseases 2022, 76: ciac477. PMID: 35717646, PMCID: PMC9384330, DOI: 10.1093/cid/ciac477.Peer-Reviewed Original ResearchMeSH KeywordsChildCOVID-19HospitalizationHumansInfluenza, HumanObesityRespiration, ArtificialRetrospective StudiesSARS-CoV-2ConceptsLife-threatening complicationsOdds of deathCoronavirus disease 2019Clinical characteristicsDisease 2019COVID-19US childrenLife supportHigher-acuity unitsInvasive mechanical ventilationShorter hospital stayNon-Hispanic blacksVasopressor supportHospital stayCritical illnessMembrane oxygenationPediatric patientsInfluenza infectionMechanical ventilationIntensive careClinical differencesUnderlying conditionDisease severityInfluenzaMixed-effects models
2020
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai SP, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. New England Journal Of Medicine 2020, 383: 334-346. PMID: 32598831, PMCID: PMC7346765, DOI: 10.1056/nejmoa2021680.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBetacoronavirusCenters for Disease Control and Prevention, U.S.ChildCoronavirus InfectionsCOVID-19Critical CareFemaleGlucocorticoidsHumansImmunoglobulins, IntravenousImmunomodulationInflammationLength of StayMaleMucocutaneous Lymph Node SyndromePandemicsPneumonia, ViralProspective StudiesRespiration, ArtificialRetrospective StudiesSARS-CoV-2Systemic Inflammatory Response SyndromeUnited StatesConceptsMultisystem inflammatory syndromeInflammatory syndromeSARS-CoV-2Antibody testingSevere acute respiratory syndrome coronavirus 2Kawasaki disease-like featuresAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Coronary artery aneurysmsIntravenous immune globulinMultisystem organ involvementEvidence of infectionOrgan system involvementSyndrome coronavirus 2Reverse transcriptase-polymerase chain reactionCoronavirus disease 2019Life-threatening illnessPediatric health centersPublic health implicationsImmunomodulating therapiesVasoactive supportImmune globulinMedian durationMost patientsOrgan involvement
2016
A regional cohort study of the treatment of critically ill children with bronchiolitis
Carroll CL, Faustino EV, Pinto MG, Sala KA, Canarie MF, Li S, Giuliano JS, Consortium T. A regional cohort study of the treatment of critically ill children with bronchiolitis. Journal Of Asthma 2016, 53: 1006-1011. PMID: 27177013, DOI: 10.1080/02770903.2016.1180697.Peer-Reviewed Original ResearchConceptsRSV bronchiolitisChildren's HospitalMechanical ventilationIll childrenChest physiotherapyICU lengthCohort studyMedical CenterConnecticut Children's Medical CenterHigh-flow nasal cannulaYale-New Haven Children's HospitalRegional cohort studyInvasive mechanical ventilationLonger ICU lengthRetrospective cohort studyRisk of intubationMortality risk scoreIntrapulmonary percussive ventilationChildren's Medical CenterUse of therapiesIntensive care courseClinical characteristicsNasal cannulaHypertonic salineMore frequent use
2013
The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children
Thompson C, Shabanova V, Giuliano JS. The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children. Pediatric Anesthesia 2013, 23: 1174-1179. PMID: 24103039, PMCID: PMC3880626, DOI: 10.1111/pan.12258.Peer-Reviewed Original ResearchConceptsState Behavioral ScalePediatric intensive care unitSNAP indexSedation levelIll childrenIll pediatric patientsIntensive care unitLevel of sedationPediatric critical careBehavioral scalesIntravenous sedationPediatric patientsSNAP-IICare unitSBS scoresSubjective sedationBedside nursesSedated childrenCritical careObservational studySedationScoring toolInformed consentPatientsBrain activity