2022
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Halasa NB, Spieker AJ, Young CC, Olson SM, Newhams MM, Amarin JZ, Moffitt KL, Nakamura MM, Levy ER, Soma VL, Talj R, Weiss SL, Fitzgerald JC, Mack EH, Maddux AB, Schuster JE, Coates BM, Hall MW, Schwartz SP, Schwarz AJ, Kong M, Spinella PC, Loftis LL, McLaughlin GE, Hobbs CV, Rowan CM, Bembea MM, Nofziger RA, Babbitt CJ, Bowens C, Flori HR, Gertz SJ, Zinter MS, Giuliano JS, Hume JR, Cvijanovich NZ, Singh AR, Crandall HA, Thomas NJ, Cullimore ML, Patel MM, Randolph AG, Kong M, Gaspers M, Typpo K, Sanders R, Katherine I, Peter M, Schwarz A, Babbitt C, Helen H, Cvijanovich N, Zinter M, Maddux A, Osborne C, Sara S, Mourani P, Emily P, Van K, Carroll C, Giuliano J, McLaughlin G, Tarquinio K, Michelson K, Coates B, Rowan C, Wellnitz K, Bhoojhawon, Sullivan J, Montgomery V, Havlin K, Bradford T, Riggs B, Bembea M, Randolph A, Newhams M, Chen S, Young C, Moffitt K, Nakamura M, Carroll R, Yager P, Fernandes N, Flori H, Heidemann S, Hume J, Levy E, Hobbs C, Martin L, Malloch L, Inagaki K, Dhanrajani A, Schuster J, Kietzman A, Hill S, Spinella P, Cullimore M, McCulloh R, Clouser K, Gertz S, Kleinman L, Li S, Horwitz S, Ratner A, Dapul H, Soma V, Keenaghan M, Singh A, Harwayne-Gidansky I, Hymes S, Doymaz S, Schwartz S, Walker T, Hall M, Shein S, Lansell A, Nofziger R, Staat M, Fitzgerald J, Weiss S, Thomas N, Fink E, Carcillo J, Mack E, Smallcomb L, Halasa N, Stewart L, Romero Y, Hayek H, Loftis L, Munoz A, Bowens C, Maamari M, Crandall H, Smith L, McGuire J. Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clinical Infectious Diseases 2022, 76: ciac477. PMID: 35717646, PMCID: PMC9384330, DOI: 10.1093/cid/ciac477.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsOdds of deathCoronavirus disease 2019Clinical characteristicsDisease 2019COVID-19US childrenLife supportHigher-acuity unitsInvasive mechanical ventilationShorter hospital stayNon-Hispanic blacksVasopressor supportHospital stayCritical illnessMembrane oxygenationPediatric patientsInfluenza infectionMechanical ventilationIntensive careClinical differencesUnderlying conditionDisease severityInfluenzaMixed-effects modelsEndothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s97-s102. PMID: 34970676, PMCID: PMC9754809, DOI: 10.1542/peds.2021-052888o.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunction syndromeOrgan dysfunction syndromeEndothelial dysfunctionIll childrenDysfunction syndromeEndothelial functionPediatric multiple organ dysfunction syndromeVascular segmentsOrgan systemsStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferencePatient-centered outcomesNon-English language studiesCombination of biomarkersData extraction formStudies of adultsCritical illnessCase seriesPremature infantsFunctional statusEligible studiesBias assessmentLeukocyte recruitment
2017
Endothelial Cell Function and Dysfunction in Critically Ill Children
Pierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children. Pediatrics 2017, 140: e20170355. PMID: 28759412, PMCID: PMC9923607, DOI: 10.1542/peds.2017-0355.Peer-Reviewed Original ResearchConceptsEndothelial cellsCritical illnessIll childrenCritically Ill ChildrenImmune cell recruitmentBiology of ECsEndothelial cell functionBroad anatomic distributionEntire vascular systemPathologic responseAnatomic distributionClinical correlationMaintenance of homeostasisBlood flowCell recruitmentBlood fluiditySystemic homeostasisCell functionSegmental differencesEC functionVascular systemIllnessChildrenHomeostasisSpecific role