2016
Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis
Telles CJ, Decker SE, Motley WW, Peters AW, Mehr AP, Frizzell RA, Forrest JN. Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis. American Journal Of Physiology - Cell Physiology 2016, 311: c884-c894. PMID: 27653983, PMCID: PMC5206301, DOI: 10.1152/ajpcell.00030.2016.Peer-Reviewed Original ResearchConceptsShark rectal glandRectal glandCFTR channelsConfocal immunofluorescent microscopyChloride secretionTASK-1 potassium channelFour-transmembraneApical chloride secretionMammalian lung tissuePotassium channelsGenomic walkingTwo-electrode voltage clampingTASK-1 proteinRapid amplificationDegenerate primersMolecular identificationMolecular identityHuman biologyAmino acidsXenopus oocytesHuman TASK-1ProteinTASK-1 channelsHuman airway cellsIdentical current-voltage relationships
2006
The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies
Mattingly CJ, Rosenstein MC, Colby GT, Forrest JN, Boyer JL. The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies. Journal Of Experimental Zoology Part A Ecological And Integrative Physiology 2006, 305A: 689-692. PMID: 16902965, PMCID: PMC1586110, DOI: 10.1002/jez.a.307.Peer-Reviewed Original ResearchConceptsComparative Toxicogenomics DatabaseCross-species comparative studiesToxicogenomics DatabaseImportant biological processesProtein functionComparative sequence studiesGenetic basisEnvironmental chemicalsBiological processesMolecular mechanismsDiverse animal modelsGenesSequence studiesIdentifies interactionsPhysiological mechanismsBasic physiological mechanismsDifferential susceptibilityEnvironmental factorsHuman healthComparative toxicological studyMost chronic diseasesToxicological studiesMechanismInteractionChemicals
2005
Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102
Weber GJ, Mehr AP, Sirota JC, Aller SG, Decker SE, Dawson DC, Forrest JN. Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102. American Journal Of Physiology - Cell Physiology 2005, 290: c793-c801. PMID: 16236827, DOI: 10.1152/ajpcell.00203.2005.Peer-Reviewed Original Research