Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis
Telles CJ, Decker SE, Motley WW, Peters AW, Mehr AP, Frizzell RA, Forrest JN. Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis. American Journal Of Physiology - Cell Physiology 2016, 311: c884-c894. PMID: 27653983, PMCID: PMC5206301, DOI: 10.1152/ajpcell.00030.2016.Peer-Reviewed Original ResearchConceptsShark rectal glandRectal glandCFTR channelsConfocal immunofluorescent microscopyChloride secretionTASK-1 potassium channelFour-transmembraneApical chloride secretionMammalian lung tissuePotassium channelsGenomic walkingTwo-electrode voltage clampingTASK-1 proteinRapid amplificationDegenerate primersMolecular identificationMolecular identityHuman biologyAmino acidsXenopus oocytesHuman TASK-1ProteinTASK-1 channelsHuman airway cellsIdentical current-voltage relationships