Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Research 1987, 415: 293-299. PMID: 3496938, DOI: 10.1016/0006-8993(87)90211-3.Peer-Reviewed Original ResearchConceptsHVA/dopamineVentral tegmental areaMPTP treatmentHomovanillic acidTegmental areaDorsal ventral tegmental areaMesolimbic DA systemCSF homovanillic acidAfrican green monkeysHVA concentrationsNigrostriatal damageMesolimbic systemTetrahydropyridine (MPTP) administrationDA lossNE concentrationCaudate nucleusNucleus accumbensParkinson's diseaseStriatal regionsPrimate brainBaseline levelsVentral partMotor disabilityMPTPGreen monkeys