1996
Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966
Horger B, Elsworth J, Roth R. Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966. Journal Of Neurochemistry 1996, 66: 1959-1962. PMID: 8780023, DOI: 10.1046/j.1471-4159.1996.66051959.x.Peer-Reviewed Original ResearchConceptsDopamine utilizationFG 7142Medial prefrontal cortexNucleus accumbensPrefrontal cortexReceptor antagonistHA-966Shell subdivisionReceptor influencesBenzodiazepine inverse agonist FG 7142Male Sprague-Dawley ratsMedia prefrontal cortexMesoaccumbal dopamine neuronsGlycine/NMDA receptor antagonistGlycine receptor antagonistSaline 15 minNMDA receptor antagonistSprague-Dawley ratsDopamine neuronsVehicle administrationSystemic administrationDihydroxyphenylacetic acidAccumbensMajor metaboliteTissue concentrations
1991
The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys
Lawrence M, Redmond D, Elsworth J, Taylor J, Roth R. The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys. Life Sciences 1991, 49: pl229-pl234. PMID: 1836030, DOI: 10.1016/0024-3205(91)90299-q.Peer-Reviewed Original ResearchConceptsSCH 23390African green monkeysD1 antagonistHealthy African green monkeysGreen monkeysParkinsonian side effectsD1 receptor antagonistPoverty of movementSigns of parkinsonismSelective D1 antagonistFull D1 agonistParkinsonian signsReceptor antagonistD1 agonistD1 receptorsSystemic administrationParkinson's diseasePsychiatric disordersSide effectsMotor changesClinical useParkinsonismAntagonistBlink rateMonkeys