Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats
Taylor J, Lewis V, Elsworth J, Pivirotto P, Roth R, Redmond D. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats. Psychopharmacology 1991, 103: 407-414. PMID: 2057541, DOI: 10.1007/bf02244297.Peer-Reviewed Original ResearchConceptsChronic morphine administrationTail-flick latencyMorphine treatmentMorphine administrationMorphine withdrawalNoradrenergic activityAlpha 2 antagonist yohimbineAlpha-2 adrenergic receptorsTail-flick analgesiaChronic drug treatmentNaloxone-precipitated withdrawalDose-dependent mannerAdrenergic hyperactivityOpioid administrationOpioid analgesiaFlick latencyNeuronal hyperactivityMorphine pelletsWithdrawal signsAbnormal postureNoradrenergic systemPenile erectionSaline controlsDrug treatmentAnalgesia