Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats
Ida Y, Elsworth J, Roth R. Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats. Pharmacology Biochemistry And Behavior 1991, 39: 791-793. PMID: 1784607, DOI: 10.1016/0091-3057(91)90166-y.Peer-Reviewed Original ResearchConceptsBrain noradrenergic activityFG 7142Specific brain regionsCerebral cortexNoradrenergic activityΒ-carboline FG 7142Brain regionsBeta-carboline FG 7142Rat brain noradrenalineBrain noradrenergic systemAntagonist Ro 15Brain noradrenalineAgonist clonidineNoradrenergic neuronsBZD receptorsMHPG levelsRo 15Sixty minNoradrenergic systemSame doseBenzodiazepine receptorsInverse agonistDihydroxyphenylglycolMajor metaboliteMetabolite levelsYohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats
Taylor J, Lewis V, Elsworth J, Pivirotto P, Roth R, Redmond D. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats. Psychopharmacology 1991, 103: 407-414. PMID: 2057541, DOI: 10.1007/bf02244297.Peer-Reviewed Original ResearchConceptsChronic morphine administrationTail-flick latencyMorphine treatmentMorphine administrationMorphine withdrawalNoradrenergic activityAlpha 2 antagonist yohimbineAlpha-2 adrenergic receptorsTail-flick analgesiaChronic drug treatmentNaloxone-precipitated withdrawalDose-dependent mannerAdrenergic hyperactivityOpioid administrationOpioid analgesiaFlick latencyNeuronal hyperactivityMorphine pelletsWithdrawal signsAbnormal postureNoradrenergic systemPenile erectionSaline controlsDrug treatmentAnalgesia