1990
MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neuroscience Letters 1990, 114: 316-322. PMID: 2402341, DOI: 10.1016/0304-3940(90)90583-u.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDopamine innervationMotor areaParkinson's diseaseMPTP-induced degenerationStriatal dopamine innervationStriatal dopamine concentrationsAsymptomatic MPTPSymptomatic MPTPConcentration of dopamineNorepinephrine levelsNorepinephrine concentrationsCortical involvementDopaminergic innervationCingulate sulcusCingulate cortexMPTPCortical regionsDopamine concentrationsInnervationDiseaseDopamineBehavioral changesCortexDegenerationMPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Research 1990, 513: 320-324. PMID: 2350702, DOI: 10.1016/0006-8993(90)90474-p.Peer-Reviewed Original ResearchConceptsVentral tegmental areaSubstantia nigraTegmental areaRetrorubral fieldParkinson's diseasePostencephalitic Parkinson's diseaseHomovanillic acid concentrationsMesostriatal dopaminergic systemIdiopathic Parkinson's diseaseAsymptomatic monkeysSymptomatic monkeysDA neuronsHVA concentrationsMPTP toxicityTreatment regimensDopaminergic systemDopamine concentrationsDA regionsDiseaseNigraDopamineParkinsonismMonkeysVervet monkeysRegimens
1988
Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation
Collier T, Redmond D, Roth R, Elsworth J, Sladek J. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation. 1988, 211-218. DOI: 10.1007/978-1-4613-0759-4_27.Peer-Reviewed Original ResearchChronic L-DOPA administrationL-DOPA administrationAfrican green monkeysNeuron transplantationExperimental parkinsonismMotor symptomsNigrostriatal systemBrain dopamineMotor abnormalitiesPreferred treatmentParkinson's diseaseL-DOPAGreen monkeysDiseaseProgressive debilitationNeurotransmitter dopamineAdministrationDopamineParkinsonismTransplantationSymptomsAbnormalitiesBrainSupplementation
1987
Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sciences 1987, 40: 193-202. PMID: 3491946, DOI: 10.1016/0024-3205(87)90359-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraParkinsonian disabilityDA neuronsSymptomatic animalsMedial regionAsymptomatic animalsHVA/DA ratioLateral regionsDA concentrationPrimate substantia nigraDA histofluorescenceNigrostriatal pathwayTetrahydropyridine (MPTP) toxicityDopaminergic neuronsContralateral halfDA ratioDopaminergic cellsLipofuscin fluorescenceCell bodiesStriatumIndividual neuronsNeuronsDifferential responsivenessMarked lossDopamine
1984
Endogenous substrates and inhibitors of monoamine oxidase
Sandler M, Glover V, Elsworth J. Endogenous substrates and inhibitors of monoamine oxidase. 1984, 187-192. DOI: 10.1007/978-1-349-86029-6_28.Peer-Reviewed Original Research
1980
Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man
Glover V, Elsworth J, Sandler M. Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man. Journal Of Neural Transmission. Supplementa 1980, 163-172. PMID: 6776235, DOI: 10.1007/978-3-7091-8582-7_18.Peer-Reviewed Original Research
1979
DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUES
Glover V, Elsworth J, Sandler M. DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUES. 1979, 201-203. DOI: 10.1016/b978-1-4832-8363-0.50063-x.Peer-Reviewed Original Research