1999
Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys
Taylor J, Elsworth J, Lawrence M, Sladek J, Roth R, Redmond D. Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys. Experimental Neurology 1999, 158: 214-220. PMID: 10448434, DOI: 10.1006/exnr.1999.7093.Peer-Reviewed Original ResearchConceptsCaudate nucleusConcentration of DAEye blink rateBlink rateDA ratioDopaminergic regulationD1 agonist dihydrexidineDA D2 receptorsDopaminergic neurotoxin MPTPSeverity of parkinsonismSpontaneous eye blink rateSpecific brain regionsAntiparkinsonian effectsDA depletionD2 agonistDopamine D1Dopamine levelsNeurotoxin MPTPD2 receptorsMPTPNormal animalsRostral portionSubcortical regionsBrain regionsVentromedial region
1990
3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation
Deutsch A, Elsworth J, Roth R, Menek G. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Research 1990, 527: 96-102. PMID: 2126479, DOI: 10.1016/0006-8993(90)91065-o.Peer-Reviewed Original ResearchConceptsCerebellar motor systemsDopamine innervationOlivocerebellar systemStriatal DA depletionStriatal dopamine innervationStriatal DA concentrationsMotor systemSelective inhibitor deprenylAnteromedial prefrontal cortexDeprenyl pretreatmentStriatal sectorsNigrostriatal degenerationDA innervationDA depletionDA levelsVentromedial striatumMAOB activitySensorimotor functionRats resultsNucleus accumbensDorsolateral aspectDorsolateral striatumMAOA activityDegenerationPrefrontal cortex