1996
Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning
Morrow B, Elsworth J, Roth R. Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning. Synapse 1996, 22: 100-105. PMID: 8787125, DOI: 10.1002/(sici)1098-2396(199602)22:2<100::aid-syn2>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexDopamine metabolismNucleus accumbensNonconditioned controlsPrefrontal cortexDopamine utilizationAdministration of haloperidolExogenous tyrosineBiosynthesis of catecholaminesDopaminergic responseDietary tyrosineRelevant doseAccumbensRatsTyrosine hydroxylationCortexGreater elevationNonconditioned ratsB-carbolineSaline/Test dayMetabolismBehavioral consequencesAversive conditioningTone
1992
Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates
Innis R, Malison R, Al‐Tikriti M, Hoffer P, Sybirska E, Seibyl J, Zoghbi S, Baldwin R, Laruelle M, Smith E, Charney D, Heninger G, Elsworth J, Roth R. Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates. Synapse 1992, 10: 177-184. PMID: 1532675, DOI: 10.1002/syn.890100302.Peer-Reviewed Original ResearchConceptsBrain uptakeD2 receptorsD2 receptor antagonist haloperidolSpecific brain uptakeStriatal dopamine levelsAdministration of haloperidolReceptor antagonist haloperidolReceptor antagonist propertiesEndogenous neurotransmitter dopamineNonhuman primate experimentsRate of washoutSingle photon emissionDopamine receptor radioligandReserpine pretreatmentEndogenous dopamineAntagonist haloperidolDopamine levelsD-amphetamineAntagonist propertiesNormothermic conditionsMin postinjectionReceptor radioligandRadioligand bindingEndogenous storesRadiotracer binding