Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation
Farrell N, Roberts J, Hacker M, Farrell N, Roberts J, Hacker M. Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation. Journal Of Inorganic Biochemistry 1991, 42: 237-246. PMID: 1880505, DOI: 10.1016/0162-0134(91)84038-b.Peer-Reviewed Original ResearchConceptsHigh-performance liquid chromatographyCarboxylate oxygenVinylic carbonBond formationAqueous solutionPerformance liquid chromatographyAcid complexesL1210 cell lineLiquid chromatographyHydrolysis productsComplexesComplex IIMajor hydrolysis productsL1210 leukemiaNovel rearrangementMoietyAntitumor activityPlatinumChromatographyReactivityOxygenPreparationCarbonComplex typeFormation