1999
Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines
Roberts J, Peroutka J, Beggiolin G, Manzotti C, Piazzoni L, Farrell N. Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines. Journal Of Inorganic Biochemistry 1999, 77: 47-50. PMID: 10626353, DOI: 10.1016/s0162-0134(99)00137-3.Peer-Reviewed Original ResearchConceptsPolynuclear platinum complexesPlatinum complexesDiamine linkerL1210 cell lineDinuclear platinum complexesTrinuclear platinum complexL1210 murine leukemia cell lineL1210/DDPDinuclear complexesAnticancer profileChemical featuresCytotoxicity profileCellular uptakeBBR3464LinkerMurine leukemia cell lineComplexesTransCharge contributesClinical agentsCytotoxicityUptake pathwayCellular accumulationAntitumor activityPlatinumCellular pharmacology of polynuclear platinum anti-cancer agents
Roberts J, Peroutka J, Farrell N. Cellular pharmacology of polynuclear platinum anti-cancer agents. Journal Of Inorganic Biochemistry 1999, 77: 51-57. PMID: 10626354, DOI: 10.1016/s0162-0134(99)00147-6.Peer-Reviewed Original ResearchConceptsCisplatin-resistant cell linesCell linesCross-linking adductsWild-type cell linesDNA repair mechanismsL1210 murine leukemia cell lineCellular pharmacologyType cell linesGenomic accessMurine leukemia cell lineWild typeCytotoxic effectsLeukemia cell linesRepair mechanismsDNA interstrandAnti-cancer agentsDiminished accumulationDinuclear platinum complexesTrinuclear platinum complexBBR3464Enhanced activityPotential anticancer agentsPotent cytotoxic agentComplexesVivo activityChemistry and Biology of Multifunctional DNA Binding Agents
Farrell N, Qu Y, Roberts J. Chemistry and Biology of Multifunctional DNA Binding Agents. Topics In Biological Inorganic Chemistry 1999, 99-115. DOI: 10.1007/978-3-662-03815-4_4.Peer-Reviewed Original Research
1991
Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation
Farrell N, Roberts J, Hacker M, Farrell N, Roberts J, Hacker M. Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation. Journal Of Inorganic Biochemistry 1991, 42: 237-246. PMID: 1880505, DOI: 10.1016/0162-0134(91)84038-b.Peer-Reviewed Original ResearchConceptsHigh-performance liquid chromatographyCarboxylate oxygenVinylic carbonBond formationAqueous solutionPerformance liquid chromatographyAcid complexesL1210 cell lineLiquid chromatographyHydrolysis productsComplexesComplex IIMajor hydrolysis productsL1210 leukemiaNovel rearrangementMoietyAntitumor activityPlatinumChromatographyReactivityOxygenPreparationCarbonComplex typeFormation
1989
Interaction of novel bis(platinum) complexes with DNA
Roberts J, Van Houten B, Qu Y, Farrell N. Interaction of novel bis(platinum) complexes with DNA. Nucleic Acids Research 1989, 17: 9719-9733. PMID: 2690006, PMCID: PMC335209, DOI: 10.1093/nar/17.23.9719.Peer-Reviewed Original Research
1988
ChemInform Abstract: Water Soluble DACH‐Pt(II) Complexes: Problems of Purification; Stability of Complexes with Nitrogen‐Containing Ligands.
ROBERTS J, SCHMIDT W, TONG W, HACKER M. ChemInform Abstract: Water Soluble DACH‐Pt(II) Complexes: Problems of Purification; Stability of Complexes with Nitrogen‐Containing Ligands. ChemInform 1988, 19: no-no. DOI: 10.1002/chin.198852282.Peer-Reviewed Original ResearchWater soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands
Roberts J, Schmidt W, Tong W, Hacker M. Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands. Inorganica Chimica Acta 1988, 153: 123-127. DOI: 10.1016/s0020-1693(00)83870-0.Peer-Reviewed Original ResearchNitrogen-containing ligandsStability of complexesTypes of complexesDicarboxylato ligandsTridentate bondingAntitumor complexesProblem of purificationAqueous solutionChemical identificationChemical formulationFurther purificationComplexesBiological systemsLigandsPurificationResidual impuritiesWaterPlatinumBondingPurityImpuritiesStabilitySolution