2013
Study Design and “Evidence” in Patient-oriented Research
Concato J. Study Design and “Evidence” in Patient-oriented Research. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 1167-1172. PMID: 23725613, DOI: 10.1164/rccm.201303-0521oe.Peer-Reviewed Original ResearchConceptsRandomized trialsObservational studyPatient-oriented researchStudy designCritical care literatureEvidence-based medicineGeneral medicalCause-effect associationClinical careGold standard statusComparative effectivenessEvidence baseTrialsCare literatureIndividual studiesPatientsStudy resultsResearch designStudyMethodological designCareEvidence approach
2010
Prostate Cancer, Comorbidity, and Participation in Randomized Controlled Trials of Therapy
Chao H, Mayer T, Concato J, Rose M, Uchio E, Kelly K. Prostate Cancer, Comorbidity, and Participation in Randomized Controlled Trials of Therapy. Journal Of Investigative Medicine 2010, 58: 566. DOI: 10.2310/jim.0b013e3181cf9002.Peer-Reviewed Original ResearchCastrate-resistant prostate cancerPhase 3 RCTsProstate cancerClinical settingPhase 3 clinical trialsVeterans Affairs Connecticut Healthcare SystemGeneral oncology practiceAbnormal laboratory valuesPopulation of patientsRandomized Controlled TrialsComplete medical recordsSerious medical conditionProportion of menBackground RandomizedChemotherapy regimensCRPC patientsControlled TrialsMedical recordsClinical trialsOncology practiceInclusion criteriaLaboratory valuesCardiac diseaseMedical conditionsClinical care