Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice
Greenwood J, Wang Y, Estrada R, Ackerman L, Ohara P, Baraban S. Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice. Annals Of Neurology 2009, 66: 644-653. PMID: 19938147, DOI: 10.1002/ana.21775.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsGlutamate-mediated excitationLis1 mutant miceHippocampal slicesMouse modelCognitive impairmentGlutamate-mediated synaptic transmissionMiniature excitatory postsynaptic currentsMutant micePaired-pulse stimulation protocolVoltage-dependent calcium channelsVideo-electroencephalographic monitoringSpontaneous electrographic seizuresAcute hippocampal slicesPatch-clamp recordingsAbnormal neuronal migrationSynaptic vesicle numberNeuronal disorganizationSynapse ultrastructureElectrographic seizuresVesicle numberSeizure activityPostsynaptic currentsVideo-EEGAdditional mice