2024
Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk
Stein M, Jain S, Papini S, Campbell-Sills L, Choi K, Martis B, Sun X, He F, Ware E, Naifeh J, Aliaga P, Ge T, Consortium F, Workgroup F, Program F, Consortium F, Smoller J, Gelernter J, Kessler R, Ursano R. Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk. Journal Of Affective Disorders 2024, 351: 671-682. PMID: 38309480, PMCID: PMC11259154, DOI: 10.1016/j.jad.2024.01.254.Peer-Reviewed Original ResearchMeSH KeywordsDepressive Disorder, MajorHumansMilitary PersonnelParentsRisk FactorsSelf-Injurious BehaviorSuicidal IdeationSuicide, AttemptedConceptsHistory of Major Depressive DisorderMajor depressive disorderNon-suicidal self-injuryLifetime non-suicidal self-injuryHistory of SAAssociated with lifetime SAParental historyMultivariate modelLifetime SASuicide attemptsParental major depressive disorderAssociated with non-suicidal self-injuryAssociated with lifetime suicide attemptsLifetime suicide attemptsClinical decision-makingDepressive disorderGWA studiesPolygenic risk scoresRisk scoreCohortEuropean ancestrySelf-injuryParental SAGenetic liabilityCombined analysis
2022
Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.
Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35802930, PMCID: PMC10859885, DOI: 10.4088/jcp.21br14309.Peer-Reviewed Original Research
2021
Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study
Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.Peer-Reviewed Original ResearchMeSH KeywordsGenome-Wide Association StudyHumansMilitary PersonnelMultifactorial InheritanceProspective StudiesStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAttachment styleU.S. military veteransIncident posttraumatic stress disorderSocial environmental factorsDevelopment of PTSDMilitary veteransInsecure attachment stylesSecure attachment stylePolygenic riskEffect of PRSLifetime trauma burdenPTSD preventionPosttraumatic stressPTSD developmentPTSD symptomsStress disorderPolygenic risk scoresHigh polygenic riskProspective designNationally RepresentativePotential pharmacotherapyMultivariate geneStyleVeteransPolygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression
Stein MB, Jain S, Campbell‐Sills L, Ware EB, Choi KW, He F, Ge T, Gelernter J, Smoller JW, Kessler RC, Ursano RJ. Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 469-475. PMID: 34288400, PMCID: PMC8692314, DOI: 10.1002/ajmg.b.32868.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepressive Disorder, MajorHumansMilitary PersonnelParentsProspective StudiesRisk FactorsSuicide, AttemptedConceptsMajor depressive disorderLifetime suicide attemptsParental historySuicide attemptsMajor depressionMDD-PRSMultivariable modelLifetime historyMajor public health problemIncident suicide attemptsPolygenic riskPublic health problemUS Army soldiersRisk stratificationDepressive disorderPolygenic risk scoresRisk scoreSecond cohortHealth problemsCommon genetic variantsFirst cohortPersonal historyCohortGenetic variantsArmy soldiersPolygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style
Asch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style. The World Journal Of Biological Psychiatry 2021, 22: 792-799. PMID: 33821766, PMCID: PMC8925016, DOI: 10.1080/15622975.2021.1907721.Peer-Reviewed Original ResearchMeSH KeywordsHumansMilitary PersonnelMultifactorial InheritanceStress Disorders, Post-TraumaticVeteransConceptsAttachment styleSecure attachment styleRe-experiencing symptomsPolygenic riskAttachment securityPsychological treatmentTraumatic eventsPositive screenPTSDStyle interactionPolygenic risk scoresUS military veteransMilitary veteransNeuroplasticity processesGenetic liabilityStyleSignificant predictorsVeteransUS veteransAssociationPredictorsScreenScoresSeverityRelationship
2019
Genome‐wide analyses of psychological resilience in U.S. Army soldiers
Stein MB, Choi KW, Jain S, Campbell‐Sills L, Chen C, Gelernter J, He F, Heeringa SG, Maihofer AX, Nievergelt C, Nock MK, Ripke S, Sun X, Kessler RC, Smoller JW, Ursano RJ. Genome‐wide analyses of psychological resilience in U.S. Army soldiers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 310-319. PMID: 31081985, PMCID: PMC6551278, DOI: 10.1002/ajmg.b.32730.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide significant lociGenome-wide significant associationGenome-wide analysisCommon variant heritabilityGenome-wide significanceIntergenic regionSecond geneSignificant lociGenetic basisMolecular basisKinase 2Association studiesMember 5Genetic determinantsDoublecortin familyLociBiological basisPolygenic risk scoresNew avenues
2018
Genome-wide analysis of insomnia disorder
Stein MB, McCarthy MJ, Chen CY, Jain S, Gelernter J, He F, Heeringa SG, Kessler RC, Nock MK, Ripke S, Sun X, Wynn GH, Smoller JW, Ursano RJ. Genome-wide analysis of insomnia disorder. Molecular Psychiatry 2018, 23: 2238-2250. PMID: 29520036, PMCID: PMC6129221, DOI: 10.1038/s41380-018-0033-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCohort StudiesDepressive Disorder, MajorDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansMaleMilitary PersonnelMultifactorial InheritancePolymorphism, Single NucleotideRisk FactorsSleep Initiation and Maintenance DisordersWhite PeopleYoung AdultConceptsGenome-wide association studiesAncestral groupsGenome-wide significant lociGenome-wide analysisGene-based associationSignificant gene-based associationsSleep-related traitsGenetic risk variantsSignificant lociChr 7Heritable basisChr 9Association studiesRisk variantsGenetic contributionLociUK BiobankMetabolic diseasesRFX3Genetic riskTraitsHeritabilityPolygenic riskTwin studiesDeleterious health effects
2017
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers
Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatrica Scandinavica 2017, 137: 148-156. PMID: 29230810, PMCID: PMC6110087, DOI: 10.1111/acps.12843.Peer-Reviewed Original ResearchConceptsBD polygenic risk scorePolygenic risk scoresAlcohol misuseBipolar disorderTrauma exposurePsychiatric disordersGenetic riskMajor depressive disorderNicotine dependence symptomsSubstance use disordersSchizophrenia polygenic risk scoresVoltage-gated calcium channel activityCalcium channel activityUS Army soldiersBeta2-adrenergic receptorDepressive disorderRisk scoreUse disordersAdrenergic receptorsMental disordersSubstance abuseDisordersDependence symptomsChannel activityExposureGenomewide association studies of suicide attempts in US soldiers
Stein MB, Ware EB, Mitchell C, Chen C, Borja S, Cai T, Dempsey CL, Fullerton CS, Gelernter J, Heeringa SG, Jain S, Kessler RC, Naifeh JA, Nock MK, Ripke S, Sun X, Beckham JC, Kimbrel NA, VA Mid‐Atlantic Mental Illness Research E, Ursano RJ, Smoller JW. Genomewide association studies of suicide attempts in US soldiers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 786-797. PMID: 28902444, PMCID: PMC5685938, DOI: 10.1002/ajmg.b.32594.Peer-Reviewed Original ResearchConceptsSuicide attemptsPlausible susceptibility geneGlobal public health problemPeak SNPPolygenic risk score analysisPublic health problemGenomewide association studiesSignificant SNPsSignificant lociGenetic risk factorsLogistic regression modelsUS military personnelAncestral groupsAssociation studiesGenomewide associationRecent suicide attemptersSusceptibility genesRisk factorsAdrenal cortexCase-control sampleRisk score analysisAncestral subgroupsLarger sample sizeBipolar disorderHealth problemsGenetic risk variants for social anxiety
Stein MB, Chen C, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J, Collaborators O. Genetic risk variants for social anxiety. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 120-131. PMID: 28224735, PMCID: PMC5325045, DOI: 10.1002/ajmg.b.32520.Peer-Reviewed Original Research
2016
Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. Army
Stein MB, Campbell‐Sills L, Gelernter J, He F, Heeringa SG, Nock MK, Sampson NA, Sun X, Jain S, Kessler RC, Ursano RJ, Collaborators S. Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. Army. Alcohol Clinical And Experimental Research 2016, 41: 139-148. PMID: 27883222, PMCID: PMC5205544, DOI: 10.1111/acer.13269.Peer-Reviewed Original ResearchConceptsAlcohol use disorderBinge drinkingAlcohol misuseMental disordersHeavy drinkingAdverse outcomesAssociation of AUDSuicidal ideationProbable alcohol use disorderOnset of AUDSubstance abuse/dependencePrior alcohol use disordersPrior mental disordersLifetime alcohol use disorderStrong bidirectional associationLifetime alcohol consumptionAbuse/dependenceCohort of soldiersBasic combat trainingDiscrete-time survival analysisOverall burdenUse disordersAlcohol consumptionDrug useSurvival analysisCross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury
Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. Journal Of Neurotrauma 2016, 34: 781-789. PMID: 27439997, PMCID: PMC5314978, DOI: 10.1089/neu.2016.4550.Peer-Reviewed Original ResearchGenome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016, 73: 695-704. PMID: 27167565, PMCID: PMC4936936, DOI: 10.1001/jamapsychiatry.2016.0350.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsCase-Control StudiesChromosomes, Human, Pair 19Chromosomes, Human, Pair 5Cohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMilitary PersonnelPolymorphism, Single NucleotideStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderTrauma-exposed controlsNew Soldier StudyRheumatoid arthritisStress disorderLifetime posttraumatic stress disorderSerious public health concernUnique participantsImmune-related disordersCumulative trauma exposureGenetic risk factorsPublic health concernLogistic regression modelsUS Army soldiersGenome-wide association studiesInflammatory disordersLifetime riskRisk factorsMAIN OUTCOMEPrimary analysisPost Deployment StudyAssociation studiesControl individualsMental disordersSignificant association