2024
Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderCase-Control StudiesCocaine-Related DisordersComorbidityDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedSeverity of Illness IndexSubstance-Related DisordersYoung AdultConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociation
2022
Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants
Overstreet C, Levey D, Zhou H, Harrington K, Quaden R, Stein M, Gelernter J, Pietrzak R, Program M. Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants. Psychiatry Research 2022, 319: 114994. PMID: 36516638, PMCID: PMC10184787, DOI: 10.1016/j.psychres.2022.114994.Peer-Reviewed Original ResearchChecklistDiagnostic and Statistical Manual of Mental DisordersFactor Analysis, StatisticalHumansSelf ReportStress Disorders, Post-TraumaticVeteransGenetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic and Statistical Manual of Mental DisordersHumansPhenotypeStress Disorders, Post-TraumaticSyndromeVeteransConceptsLocal genetic correlationsCell type-specific expressionVanderbilt University biorepositoryMulti-omics studiesMulti-omics investigationsDorsolateral prefrontal cortex tissueGenomic evidenceLaboratory traitsSpecific expressionCardio-metabolic traitsMillion Veteran ProgramPrefrontal cortex tissueMiR-148GenesGenetic correlationsRegulatory profileTraitsProtein expressionCardiometabolic traitsExpressionVeteran ProgramCortex tissueBiological heterogeneitySplicingPrioritization approach
2021
Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug And Alcohol Dependence 2021, 229: 109047. PMID: 34710713, DOI: 10.1016/j.drugalcdep.2021.109047.Peer-Reviewed Original ResearchAlcoholismAmphetamine-Related DisordersChinaDiagnostic and Statistical Manual of Mental DisordersHumansMethamphetamineReproducibility of Results
2017
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression
Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry 2017, 74: 1234-1241. PMID: 29071344, PMCID: PMC6331050, DOI: 10.1001/jamapsychiatry.2017.3275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanComorbidityDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedMultifactorial InheritanceOrgan SizePutamenSemaphorin-3AUnited StatesWhite PeopleConceptsGenome-wide association studiesGenetic risk variantsNeuropsychiatric traitsAssociation studiesRisk variantsPolygenic risk allelesPolygenic risk scoresGenetic mechanismsGenetic basisAmerican data setMolecular natureTraitsCriterion countsGenetic causePossible genetic causesMD comorbidityRisk allelesComorbid alcohol dependence
2016
A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke
Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Molecular Psychiatry 2016, 22: 242-249. PMID: 27067016, PMCID: PMC5390815, DOI: 10.1038/mp.2016.43.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCadherinsDiagnostic and Statistical Manual of Mental DisordersFemaleGene Expression RegulationGenome-Wide Association StudyHumansMaleMultigene FamilyNicotinePolymorphism, Single NucleotideProtocadherinsRecurrenceSmokingSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderWhite PeopleConceptsNicotine withdrawalSingle nucleotide polymorphismsNovel smoking cessation treatmentsAfrican AmericansSmoking cessation treatmentNicotine withdrawal symptomsOvernight smoking abstinenceEuropean American smokersFrontal cortex tissueΓ geneCessation treatmentTobacco smokingSmoking abstinenceWithdrawal symptomsAbstinent smokersAmerican smokersΓ gene expressionNicotine infusionSmoking urgesInfusion studiesSmokersMRNA expressionRisk allelesCortex tissueBrief questionnaire
2015
Inter-observer reliability of DSM-5 substance use disorders
Denis CM, Gelernter J, Hart AB, Kranzler HR. Inter-observer reliability of DSM-5 substance use disorders. Drug And Alcohol Dependence 2015, 153: 229-235. PMID: 26048641, PMCID: PMC4509850, DOI: 10.1016/j.drugalcdep.2015.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMood DisordersObserver VariationSubstance-Related DisordersConceptsDSM-5 SUD diagnosesSUD diagnosisDSM-IV diagnosisLifetime moodInter-observer reliabilityDSM-5 substance use disordersDisorder diagnosisCo-occurring SUDSubstance use disorder diagnosisSubstance use disordersDSM-5 criteriaSemi-Structured AssessmentAnxiety disorder diagnosisLifetime SUDMild severityUse disordersDrug dependenceSevere disordersDSM-IVPercent agreementDiagnosisAnxiety disordersLifetime alcoholLimited evidenceDisorders
2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effectsDSM-5 Gambling Disorder: Prevalence and Characteristics in a Substance Use Disorder Sample
Rennert L, Denis C, Peer K, Lynch KG, Gelernter J, Kranzler HR. DSM-5 Gambling Disorder: Prevalence and Characteristics in a Substance Use Disorder Sample. Experimental And Clinical Psychopharmacology 2014, 22: 50-56. PMID: 24490711, PMCID: PMC4019046, DOI: 10.1037/a0034518.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedDiagnostic and Statistical Manual of Mental DisordersFemaleGamblingHumansLogistic ModelsMaleMiddle AgedPrevalenceSensitivity and SpecificitySubstance-Related DisordersYoung AdultConceptsSubstance Use Disorder SamplePathological gamblingGD diagnosisSemistructured psychiatric interviewFourth Edition diagnosisLogistic regression analysisGambling disorderDSM-5 diagnosisMultinomial logistic regression analysisDisorder sampleProspective studySUD sampleEdition diagnosisHigh prevalenceComorbid SUDPG criteriaPsychiatric interviewMental disordersDSM-IVSubstance dependenceDiagnosisPrevalenceStatistical ManualRegression analysisFifth edition
2013
Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM‐IV cocaine dependence as traits for genetic association analysis
Bi J, Gelernter J, Sun J, Kranzler HR. Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM‐IV cocaine dependence as traits for genetic association analysis. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 165: 148-156. PMID: 24339190, PMCID: PMC4152729, DOI: 10.1002/ajmg.b.32216.Peer-Reviewed Original ResearchAdultChromosome MappingCocaine-Related DisordersDiagnostic and Statistical Manual of Mental DisordersFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMalePolymorphism, Single NucleotideYoung Adult
2012
Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample
Peer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR. Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample. Drug And Alcohol Dependence 2012, 127: 215-219. PMID: 22884164, PMCID: PMC3727225, DOI: 10.1016/j.drugalcdep.2012.07.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCase-Control StudiesCocaine-Related DisordersDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMarijuana AbuseMiddle AgedOpioid-Related DisordersPrevalenceSubstance-Related DisordersConceptsSubstance use disordersSUD diagnosisDSM-IVDiagnosis of SUDDSM-5DSM-5 substance use disordersDSM-5 SUD diagnosesDiagnostic orphansSevere substance use disordersLimited diagnostic utilityDSM-5 diagnosisDSM-5 alcoholSemi-Structured AssessmentDSM-IV abuseDiagnostic switchLifetime presenceClinical careDiagnostic criteriaGreater prevalenceUse disordersDiagnostic utilityDependence diagnosisMental disordersDrug dependenceSubstance dependence
2011
Variation in OPRM1 and Risk of Suicidal Behavior in Drug‐Dependent Individuals
Arias AJ, Chan G, Gelernter J, Farrer L, Kranzler HR. Variation in OPRM1 and Risk of Suicidal Behavior in Drug‐Dependent Individuals. American Journal On Addictions 2011, 21: 5-10. PMID: 22211341, PMCID: PMC3674102, DOI: 10.1111/j.1521-0391.2011.00195.x.Peer-Reviewed Original ResearchAdultDiagnostic and Statistical Manual of Mental DisordersFemaleHumansInterview, PsychologicalMalePolymorphism, Single NucleotideReceptors, Opioid, muRisk FactorsSubstance-Related DisordersSuicidal IdeationSuicide, AttemptedSynaptic TransmissionEmpirically derived subtypes of opioid use and related behaviors
Chan G, Gelernter J, Oslin D, Farrer L, Kranzler HR. Empirically derived subtypes of opioid use and related behaviors. Addiction 2011, 106: 1146-1154. PMID: 21306596, PMCID: PMC3164489, DOI: 10.1111/j.1360-0443.2011.03390.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAnalgesics, OpioidChildCluster AnalysisComorbidityDiagnostic and Statistical Manual of Mental DisordersFamily HealthFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInterview, PsychologicalMaleMental DisordersMiddle AgedOpioid-Related DisordersPhenotypePrevalenceSiblingsSubstance Abuse, IntravenousUnited StatesYoung AdultConceptsOpioid usePsychiatric disordersHomogeneous subtypesRelated behaviorsSemi-Structured AssessmentGeneral community sampleOpioid dependenceMedical historyPrevalence ratesCocaine dependenceDrug dependenceSubtypesParticipant demographicsSubstance useCase-control genetic studyDemographicsDisordersCommunity sampleGenetic studiesInter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, Gueorguieva R, Kranzler HR, Gelernter J. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addictive Behaviors 2011, 36: 156-160. PMID: 20888699, PMCID: PMC2981662, DOI: 10.1016/j.addbeh.2010.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiagnostic and Statistical Manual of Mental DisordersEthnicityFemaleHumansInterview, PsychologicalMaleMass ScreeningOpioid-Related DisordersReproducibility of ResultsSurveys and QuestionnairesThailand
2009
Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations
Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations. JAMA Psychiatry 2009, 66: 1201-1209. PMID: 19884608, PMCID: PMC2867334, DOI: 10.1001/archgenpsychiatry.2009.153.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanChildChild AbuseCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleGenetic Predisposition to DiseaseGenotypeHomozygoteHumansLife Change EventsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial EnvironmentStress Disorders, Post-TraumaticSubstance-Related DisordersWhite PeopleConceptsAdult traumatic eventsPosttraumatic stress disorderLifetime posttraumatic stress disorderChildhood adversityStressful life eventsTraumatic eventsDSM-IV diagnostic criteriaOnset of PTSDCross-sectional studyStress disorder diagnosisPosttraumatic stress disorder (PTSD) diagnosisLogistic regression modelingLife eventsSemi-Structured AssessmentEtiology of PTSDAdverse eventsAfrican American individualsDepressive symptomsDiagnostic criteriaSerotonin transporter geneDrug dependenceTrauma exposureStress disorderGene x environment interactionsSubstance dependenceSources of unreliability in the diagnosis of substance dependence.
Feinn R, Gelernter J, Cubells JF, Farrer L, Kranzler HR. Sources of unreliability in the diagnosis of substance dependence. Journal Of Studies On Alcohol And Drugs 2009, 70: 475-81. PMID: 19371499, PMCID: PMC2670752, DOI: 10.15288/jsad.2009.70.475.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleModels, StatisticalObserver VariationReproducibility of ResultsSubstance-Related DisordersConceptsSubstance dependence diagnosesDrug dependenceCommon diagnosisCriterion countsSemi-Structured AssessmentOpioid dependencePsychiatric disordersMost diagnosesOccasion variabilityMental disordersSubstance dependenceDiagnosisStatistical ManualMarijuana dependenceReliable diagnosisFourth EditionDependence categoriesSubjects' reportsSubjectsExcellent reliabilityDisordersCountIndex of dependabilityReportInterviewersAssociation of Variants in MANEA With Cocaine-Related Behaviors
Farrer LA, Kranzler HR, Yu Y, Weiss RD, Brady KT, Anton R, Cubells JF, Gelernter J. Association of Variants in MANEA With Cocaine-Related Behaviors. JAMA Psychiatry 2009, 66: 267-274. PMID: 19255376, PMCID: PMC2758158, DOI: 10.1001/archgenpsychiatry.2008.538.Peer-Reviewed Original ResearchAdultAllelesChromosome MappingCocaine-Related DisordersDiagnostic and Statistical Manual of Mental DisordersFemaleGene ExpressionGenetic VariationGenotypeHaplotypesHumansMaleMannosidasesPolymorphism, Single NucleotidePrevalenceRacial Groups
2008
RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults
Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults. Depression And Anxiety 2008, 26: 309-315. PMID: 18833580, PMCID: PMC2666784, DOI: 10.1002/da.20528.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAnxiety DisordersCyclonic StormsDiagnostic and Statistical Manual of Mental DisordersFeasibility StudiesFemaleFloridaGenotypeHumansLife Change EventsMaleMiddle AgedPolymorphism, Single NucleotidePrevalenceRGS ProteinsStress Disorders, Post-TraumaticYoung AdultConceptsEpidemiologic sampleC alleleAnxiety disordersRisk of GADRandom digit dial proceduresSingle nucleotide polymorphismsLogistic regression analysisPanic disorder patientsDSM-IV diagnosisGeneralized anxiety disorderHurricane exposureFlorida Hurricane StudyRGS2 geneSocial supportStressful life eventsHigh prevalenceOutcome measuresDisorder patientsPanic disorderBuccal DNA samplesRelevant polymorphismsDisordersGADAnxious behaviorGAD symptoms
2007
The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults
Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults. American Journal Of Psychiatry 2007, 164: 1693-1699. PMID: 17974934, DOI: 10.1176/appi.ajp.2007.06122007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersDisastersFemaleFloridaGenetic VariationGenotypeHumansLife Change EventsLogistic ModelsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial SupportStress Disorders, Post-TraumaticConceptsHigh hurricane exposurePosttraumatic stress disorderLow social supportMajor depressionLow-expression variantPostdisaster posttraumatic stress disorderSocial supportStress disorderHurricane exposureHigh-risk individualsDSM-IV diagnosisLow-risk individualsAdults ages 18Household probability sampleSubset of participantsOutcome measuresAdults 6Serotonin transporter genotypeSerotonin transporter geneAge 18DepressionDisaster exposureTransporter genotypeRiskStructured interviewsComorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects
Tang Y, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects. American Journal On Addictions 2007, 16: 343-351. PMID: 17882604, DOI: 10.1080/10550490701525723.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAttention Deficit Disorder with HyperactivityCocaineCocaine-Related DisordersComorbidityDemographyDiagnosis, Dual (Psychiatry)Diagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMental DisordersPrevalencePsychoses, Substance-InducedSmokingConceptsAttention deficit hyperactivity disorderCocaine-Induced PsychosisComorbid substance useAntisocial personality disorderCocaine Experience QuestionnairePsychiatric disordersUse disordersPsychiatric diagnosisCocaine dependenceAxis I psychiatric diagnosesComorbid opioid dependenceSubstance useAdult antisocial personality disorderComorbid attention deficit hyperactivity disorderPercent of subjectsComorbid psychiatric diagnosesDSM-IV diagnosisSubstance use disordersCocaine-dependent adultsCocaine-dependent subjectsCocaine-dependent sampleSemi-Structured AssessmentDrugs of abuseDeficit hyperactivity disorderSuch comorbidities