2020
Transcriptomic organization of the human brain in post-traumatic stress disorder
Girgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutopsyBrain ChemistryCohort StudiesDepressive Disorder, MajorFemaleGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterneuronsMaleMiddle AgedNerve Tissue ProteinsSex CharacteristicsStress Disorders, Post-TraumaticTranscriptomeYoung AdultConceptsGenome-wide association studiesSignificant gene networksDifferential gene expressionSystems-level evidenceSignificant genetic liabilityMajor depressive disorder cohortGene networksTranscriptomic organizationTranscriptomic landscapeDownregulated setsGenomic networksGene expressionAssociation studiesMolecular determinantsExtensive remodelingGenotype dataSexual dimorphismSignificant divergenceMolecular profileNetwork analysisELFN1TranscriptsDimorphismPostmortem tissueDivergence
2017
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder
Martin J, Walters R, Demontis D, Mattheisen M, Lee S, Robinson E, Brikell I, Ghirardi L, Larsson H, Lichtenstein P, Eriksson N, Agee M, Alipanahi B, Auton A, Bell R, Bryc K, Elson S, Fontanillas P, Furlotte N, Hinds D, Hromatka B, Huber K, Kleinman A, Litterman N, McIntyre M, Mountain J, Northover C, Pitts S, Sathirapongsasuti J, Sazonova O, Shelton J, Shringarpure S, Tian C, Tung J, Vacic V, Wilson C, Albayrak Ö, Anney R, Vasquez A, Arranz M, Asherson P, Banaschewski T, Banaschewski T, Bau C, Biederman J, Mortensen P, Børglum A, Buitelaar J, Casas M, Charach A, Cormand B, Crosbie J, Dalsgaard S, Daly M, Demontis D, Dempfle A, Doyle A, Ebstein R, Elia J, Faraone S, Faraone S, Föcker M, Franke B, Freitag C, Gelernter J, Gill M, Grevet E, Haavik J, Hakonarson H, Hawi Z, Hebebrand J, Herpertz-Dahlmann B, Hervas A, Hinney A, Hohmann S, Holmans P, Hutz M, Ickowitz A, Johansson S, Kent L, Kittel-Schneider S, Kranzler H, Kuntsi J, Lambregts-Rommelse N, Langley K, Lehmkuhl G, Lesch K, Loo S, Martin J, McGough J, Medland S, Meyer J, Mick E, Middletion F, Miranda A, Mulas F, Mulligan A, Neale B, Nelson S, Nguyen T, O’Donovan M, Oades R, Owen M, Palmason H, Ramos-Quiroga J, Reif A, Renner T, Rhode L, Ribasés M, Rietschel M, Ripke S, Rivero O, Roeyers H, Romanos M, Romanos J, Mota N, Rothenberger A, Sánchez-Mora C, Schachar R, Schäfer H, Scherag A, Schimmelmann B, Sergeant J, Sinzig J, Smalley S, Sonuga-Barke E, Steinhausen H, Sullivan P, Thapar A, Thompsom M, Todorov A, Waldman I, Walitza S, Walters R, Wang Y, Warnke A, Williams N, Witt S, Yang L, Zayats T, Zhang-James Y, Agerbo E, Als T, Bækved-Hansen M, Belliveau R, Børglum A, Bybjerg-Grauholm J, Cerrato F, Chambert K, Churchhouse C, Dalsgaard S, Daly M, Demontis D, Dumont A, Goldstein J, Grove J, Hansen C, Hauberg M, Hollegaard M, Hougaard D, Howrigan D, Huang H, Maller J, Martin A, Martin J, Mattheisen M, Moran J, Mors O, Mortensen P, Neale B, Nordentoft M, Pallesen J, Palmer D, Pedersen C, Pedersen M, Poterba T, Poulsen J, Ripke S, Robinson E, Satterstrom F, Stevens C, Turley P, Walters R, Werge T, Werge T, Mortensen P, Pedersen M, Mors O, Nordentoft M, Hougaard D, Bybjerg-Grauholm J, Wray N, Franke B, Faraone S, O’Donovan M, Thapar A, Børglum A, Neale B. A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2017, 83: 1044-1053. PMID: 29325848, PMCID: PMC5992329, DOI: 10.1016/j.biopsych.2017.11.026.Peer-Reviewed Original ResearchLargest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry 2017, 23: 666-673. PMID: 28439101, PMCID: PMC5696105, DOI: 10.1038/mp.2017.77.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBlack or African AmericanCase-Control StudiesDepressive Disorder, MajorFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritancePolymorphism, Single NucleotideRisk FactorsSchizophreniaSex CharacteristicsSex FactorsStress Disorders, Post-TraumaticWhite PeopleConceptsSingle nucleotide polymorphismsRisk lociSNP-level summary statisticsGenomic data resourcesGenome-wide significanceMolecular genetic dataComplex genetic disorderPolygenic risk predictionGenetic dataAncestral diversityLarge GWASGenetic indicesDiverse phenotypesGenetic riskHeritability estimatesLociSummary statisticsGenetic disordersHeritabilityGenetic influencesGWASDiversityPhenotypeTransethnicStrong evidence
2016
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits
Polimanti R, Yang BZ, Zhao H, Gelernter J. Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. PLOS ONE 2016, 11: e0160654. PMID: 27537407, PMCID: PMC4990182, DOI: 10.1371/journal.pone.0160654.Peer-Reviewed Original ResearchConceptsPolygenic adaptationNatural selectionSystems geneticsProtein interaction networksWide association studyPolygenic mechanismsEuropean populationsPolygenic selectionAnthropometric traitsGene networksHuman genomeEpistatic interactionsInteraction networksEnrichment analysisGenetic signaturesSystems biologyAssociation studiesLipid transportMolecular processesAdaptation signalsLocomotory behaviorTraitsSelective mechanismGeneticsInfection resistance
2012
Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study
Jamadar S, Powers NR, Meda SA, Calhoun VD, Gelernter J, Gruen JR, Pearlson GD. Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study. Brain Imaging And Behavior 2012, 7: 15-27. PMID: 22669497, PMCID: PMC4428558, DOI: 10.1007/s11682-012-9168-1.Peer-Reviewed Original Research
2009
Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample
Amstadter AB, Nugent NR, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample. Psychiatry 2009, 72: 360-369. PMID: 20070134, PMCID: PMC2808117, DOI: 10.1521/psyc.2009.72.4.360.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCigarette smokingCOMT Val158MetFrequency of smokingSaliva DNA samplesFirst genetic association studyFlorida Hurricane StudyAge of initiationCOMT Val158Met polymorphismTobacco smokingSmokingEpidemiologic samplePossible associationAcute stressorStress disorderVal158Met polymorphismHurricane exposureTraumatic eventsGenetic association studiesVal158MetAssociationEuropean American malesDNA samplesAssociation studiesInitiation
2004
A polymorphism of the β1-adrenergic receptor is associated with low extraversion
Stein MB, Schork NJ, Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with low extraversion. Biological Psychiatry 2004, 56: 217-224. PMID: 15312808, DOI: 10.1016/j.biopsych.2004.05.020.Peer-Reviewed Original ResearchAdolescentAdultArginineChi-Square DistributionCluster AnalysisEthnicityExtraversion, PsychologicalFemaleGene FrequencyGlycineHumansMalePersonality InventoryPhenotypePolymorphism, GeneticPsychiatric Status Rating ScalesReceptors, Adrenergic, beta-1Regression AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSerineSex CharacteristicsSurveys and Questionnaires
1995
Genetics of bipolar affective disorder: time for another reinvention?
Gelernter J. Genetics of bipolar affective disorder: time for another reinvention? American Journal Of Human Genetics 1995, 56: 1262-6. PMID: 7762549, PMCID: PMC1801084.Peer-Reviewed Original Research
1992
Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM
Gelernter J, Pakstis AJ, Grandy D, Litt M, Retief AE, Kennedy JL, Hing-Loh A, Schoolfield G, Civelli O, Kidd KK. Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM. Cytogenetic And Genome Research 1992, 60: 26-28. PMID: 1349858, DOI: 10.1159/000133287.Peer-Reviewed Original Research