2021
Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms
Pathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms. Circulation Genomic And Precision Medicine 2021, 14: e003011. PMID: 33428857, PMCID: PMC7887108, DOI: 10.1161/circgen.120.003011.Peer-Reviewed Original ResearchAmyloidosisATP Binding Cassette Transporter 1Black or African AmericanDNA MethylationEpigenomicsGene Regulatory NetworksGenome-Wide Association StudyHeart DiseasesHumansKv1.6 Potassium ChannelPhosphoproteinsPolymorphism, Single NucleotidePrealbuminQuantitative Trait LociUbiquitin-Conjugating Enzymes
2011
GABRA2 and KIBRA genotypes predict early relapse to substance use
Bauer LO, Covault J, Gelernter J. GABRA2 and KIBRA genotypes predict early relapse to substance use. Drug And Alcohol Dependence 2011, 123: 154-159. PMID: 22129841, PMCID: PMC3294190, DOI: 10.1016/j.drugalcdep.2011.11.004.Peer-Reviewed Original ResearchConceptsMonths of abstinenceDrug use problemsCognitive controlContribution of ageAbstinence violationDrug abuse problemsKIBRA genotypeUse problemsDepression symptomsDrug involvementSubstance useAbuse problemsTreatment settingsDrug useKIBRARisk of relapseFuture studiesGABRA2AbstinenceSmall samplesEthnic groupsANKK1Younger age
2009
Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use
Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use. Neuropsychopharmacology 2009, 34: 2508-2516. PMID: 19606085, PMCID: PMC2898508, DOI: 10.1038/npp.2009.80.Peer-Reviewed Original ResearchConceptsCognitive flexibilityPerseverative errorsPerseverative responsesWisconsin Card Sorting TestMemory performance measuresCard Sorting TestSorting TestRs17070145Main effectInteraction effectsEuropean AmericansRecencyPopulation-specific wayRecent tobacco usePerformance measuresTobacco useSynaptic plasticityModeratesKIBRAAfrican AmericansSmokersFlexibility
2008
Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents
Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents. Biological Psychiatry 2008, 65: 671-679. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAllelic ImbalanceBrainCalcium-Binding ProteinsFemaleGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMemory DisordersPhosphoproteinsPregnancyPrenatal Exposure Delayed EffectsProteinsTemporal LobeTobacco Smoke PollutionConceptsAdolescent exposureCalsyntenin-2Visuospatial memoryMedial temporal lobe functionRecall of wordsRecognition memory taskFunctional magnetic resonance imaging (fMRI) dataTemporal lobe functionEnhanced functional connectivityMemory taskVerbal recallMnemonic processingVerbal recognitionIndividual differencesAdolescent developmentLobe functionKIBRA genotypeDependent measuresMagnetic resonance imaging dataFunctional connectivityParahippocampal gyrusSubsequent deficitsBrain regionsMemoryAdolescents