2002
Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion
Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Molecular Psychiatry 2002, 7: 213-216. PMID: 11840315, DOI: 10.1038/sj.mp.4000962.Peer-Reviewed Original ResearchConceptsHamilton Depression Rating ScaleTRP depletionTryptophan depletionMajor depressive episodeDepression Rating ScaleDepressive symptom responseMood responsesPromoter region polymorphismsDepressive episodeSymptom responseBlood lymphocytesDepressive symptomsAffective disordersDepressive responseSerotonin transporter geneDepressive changesSignificant associationEndophenotypic markerFunctional polymorphismsRating ScaleCheek cellsRegion polymorphismsSignificant main effectHomozygous genotypeTransporter activity
2001
Family‐based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits
Zalsman G, Frisch A, Bromberg M, Gelernter J, Michaelovsky E, Campino A, Erlich Z, Tyano S, Apter A, Weizman A. Family‐based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits. American Journal Of Medical Genetics 2001, 105: 239-245. PMID: 11353442, DOI: 10.1002/ajmg.1261.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarrier ProteinsFamily HealthFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansIsraelMaleMembrane GlycoproteinsMembrane Transport ProteinsMental DisordersNerve Tissue ProteinsPhenotypePolymorphism, GeneticPromoter Regions, GeneticPsychology, AdolescentSerotonin Plasma Membrane Transport ProteinsSuicide, AttemptedViolenceConceptsSuicidal behaviorDetailed clinical historySerotonin transporter promoterSuicide-related behaviorsPromoter region polymorphismsSerotonin dysfunctionClinical parametersClinical historyBlood samplesHaplotype relative risk methodRelative risk methodSuicidal adolescentsSuicide riskLS genotypeAdolescent inpatientsAnxiety disordersSuicide intentSignificant allelic associationSuicidal adolescent inpatientsSignificant differencesFamily-based association studyPatientsRegion polymorphismsTransporter promoterPossible role