Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function
Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function. JAMA Psychiatry 2008, 65: 298-308. PMID: 18316676, DOI: 10.1001/archgenpsychiatry.2007.48.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonanceHuman anxiety disordersAnxiety disordersEmotional facesEmotion processingChildhood temperamentLaboratory-based behavioral measuresSocial anxiety disorderBrain functionChildhood behavioral inhibitionSelf-report measuresInsular cortex activationIndependent samplesLaboratory-based assessmentsTemperamental precursorsBehavioral inhibitionBehavioral measuresAdult personalityCortex activationLimbic activationAnxiety phenotypeTemperamentIntermediate phenotypesAnxietyAnxiety behavior