2024
Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociation
2021
Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
Sherva R, Zhu C, Wetherill L, Edenberg HJ, Johnson E, Degenhardt L, Agrawal A, Martin NG, Nelson E, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. Exploration Of Medicine 2021, 2: 60-73. PMID: 34124712, PMCID: PMC8192073, DOI: 10.37349/emed.2021.00032.Peer-Reviewed Original ResearchCox proportional hazards regressionProportional hazards regressionAfrican AmericansDiscovery sampleSelf-reported useSubstantial morbidityHazards regressionHealth burdenIndependent cohortSubstance dependence phenotypesDependence diagnosisGenetic risk lociReplication cohortCocaine dependenceOpioidsDependence phenotypesCohortGenetic variantsTop findingsCocaineRisk lociDisorder resultsLarge percentage
2019
Differentiating Types of Self-Reported Alcohol Abstinence
Gordon KS, McGinnis K, Dao C, Rentsch CT, Small A, Smith RV, Kember RL, Gelernter J, Kranzler HR, Bryant KJ, Tate JP, Justice AC. Differentiating Types of Self-Reported Alcohol Abstinence. AIDS And Behavior 2019, 24: 655-665. PMID: 31435887, PMCID: PMC6994373, DOI: 10.1007/s10461-019-02638-x.Peer-Reviewed Original ResearchConceptsLifetime abstainersSelf-reported alcohol abstinenceAlcohol biomarkersGenetic polymorphismsLogistic regression modelsHepatitis CAlcohol abstinenceUninfected individualsCharacteristics of peopleAlcohol useAbstinenceHealth effectsSmokingAbstainersBiomarkersRegression modelsOddsAssociationPLWHPolymorphismHIVCocaine
2011
Agitated depression in substance dependence
Leventhal AM, Gelernter J, Oslin D, Anton RF, Farrer LA, Kranzler HR. Agitated depression in substance dependence. Drug And Alcohol Dependence 2011, 116: 163-169. PMID: 21277711, PMCID: PMC3105217, DOI: 10.1016/j.drugalcdep.2010.12.012.Peer-Reviewed Original ResearchConceptsSubstance dependenceOpioid dependenceDSM-IV mental disordersMajor depressive episodeNon-opioid formsLifetime substance dependenceDepression associatesMDE subtypesSedative dependencePsychomotor agitationDepressive episodeDepression subtypesLifetime depressionOpioidsDrug dependenceMental disordersSubtypesCocaineDrugsDepressionPsychiatric phenotypesStructured interviewsPMAAssociationComorbidities
2009
Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).
Tang YL, Kranzler HR, Gelernter J, Farrer LA, Pearson D, Cubells JF. Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP). American Journal On Addictions 2009, 18: 339-45. PMID: 19874151, PMCID: PMC2878659, DOI: 10.3109/10550490903077937.Peer-Reviewed Original ResearchConceptsCocaine-induced psychosisProportion of subjectsBehavioral symptomsSAPS-CIPAgitated behaviorsPositive symptomsStereotyped behaviorSevere behavioral symptomsSexual behaviorCocaine-dependent subjectsCommon vulnerability factorsChronic useSeverity scorePsychotic symptomsCocaine useSymptomsPsychosisSubstantial minorityCurrent reportSubjectsCocaineHallucinationsAdverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders
Douglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR. Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders. Addictive Behaviors 2009, 35: 7-13. PMID: 19720467, PMCID: PMC2763992, DOI: 10.1016/j.addbeh.2009.07.004.Peer-Reviewed Original ResearchConceptsAdverse childhood eventsSD riskSubstance dependenceAnxiety disordersRisk factorsNegative health outcomesSemi-Structured AssessmentChildhood eventsOpioid dependenceSD diagnosisLifetime moodEffective treatmentLifetime diagnosisFirst onsetHealth outcomesDrug dependenceEarly life experiencesDisordersChildhood abuseRiskMoodDiagnosisAlcoholismCocaine