Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y
Berrettini W, Garrick N, Nurnberger J, Simmons-Alling S, Gelernter J, Gold P, Rubinow D, Murphy D. Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y. Biological Psychiatry 1989, 26: 623-630. PMID: 2790099, DOI: 10.1016/0006-3223(89)90087-5.Peer-Reviewed Original ResearchConceptsIntravenous infusionMicrograms/Central nervous system neurotransmittersAcute pharmacological challengePharmacological challenge paradigmsAcute intravenous infusionSerial CSF samplesDose-time interactionUseful clinical toolNormal human subjectsCholinergic agonist physostigmineCerebrospinal fluid neuropeptidesCSF NPYPhysostigmine infusionStimulus-induced responsesIntravenous physostigmineCSF levelsCSF cathetersCSF neuropeptidesNeuropeptide changesPharmacological challengeCSF samplesClinical toolRhesus monkeysPhysostigmine