2011
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter AB, Daughters SB, MacPherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance. Journal Of Psychiatric Research 2011, 46: 87-94. PMID: 22024485, PMCID: PMC3687355, DOI: 10.1016/j.jpsychires.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCatechol O-MethyltransferaseChildChi-Square DistributionDistrict of ColumbiaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansLongitudinal StudiesMaleMood DisordersPolymorphism, Single NucleotidePsychiatric Status Rating ScalesRegression AnalysisRisk-TakingSerotonin Plasma Membrane Transport ProteinsConceptsEmotion regulation difficultiesDistress intoleranceBehavioral measuresPoor psychological functioningAdolescent risk behaviorsDistress tolerancePsychological functioningLarger longitudinal studyVal allele carriersYear old youthMet homozygotesEmotional abuseBehavioral indicatorsBehavioral assessmentLongitudinal studyGenetic influencesCandidate genetic polymorphismsTaskYouthDistressExploratory analysisRisk behaviorsEmpirical evidencePrior studiesDifficulties
2008
Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function
Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function. JAMA Psychiatry 2008, 65: 298-308. PMID: 18316676, DOI: 10.1001/archgenpsychiatry.2007.48.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonanceHuman anxiety disordersAnxiety disordersEmotional facesEmotion processingChildhood temperamentLaboratory-based behavioral measuresSocial anxiety disorderBrain functionChildhood behavioral inhibitionSelf-report measuresInsular cortex activationIndependent samplesLaboratory-based assessmentsTemperamental precursorsBehavioral inhibitionBehavioral measuresAdult personalityCortex activationLimbic activationAnxiety phenotypeTemperamentIntermediate phenotypesAnxietyAnxiety behavior