Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis
Kleiman T, Zdanys K, Black B, Rightmer T, Grey M, Garman K, MacAvoy M, Gelernter J, van Dyck C. Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis. Dementia And Geriatric Cognitive Disorders 2006, 22: 73-82. PMID: 16699282, DOI: 10.1159/000093316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional declineProspective analysisAD patientsEpsilon4 doseMultiple subsequent time pointsApolipoprotein E (APOE) ε4 alleleGenotype groupsApolipoprotein E epsilon4 alleleDuration of symptomsAD patient samplesGenetic risk factorsSubsequent time pointsTests of cognitionRisk factorsAPOE epsilon4Disease onsetDisease progressionEpsilon4 alleleFunctional impairmentRetrospective analysisΕ4 alleleDaily functionPatient samplesFunctional measures