2021
The narrowing of dendrite branches across nodes follows a well-defined scaling law
Liao M, Liang X, Howard J. The narrowing of dendrite branches across nodes follows a well-defined scaling law. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2022395118. PMID: 34215693, PMCID: PMC8271565, DOI: 10.1073/pnas.2022395118.Peer-Reviewed Original Research
2019
Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules
Kuo YW, Trottier O, Mahamdeh M, Howard J. Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 5533-5541. PMID: 30837315, PMCID: PMC6431158, DOI: 10.1073/pnas.1818824116.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAdenosine TriphosphateAnimalsDrosophila melanogasterDrosophila ProteinsMicrotubulesSpastinConceptsDual-function enzymeMicrotubule dynamicsMass of microtubulesMicrotubule cytoskeletonDynamic cellular processesCellular processesMicrotubule regrowthNeuronal morphogenesisSevering activityVivo phenotypeMicrotubule assaysMicrotubulesNumber of microtubulesSpastinMicrotubule fragmentsRescue frequencyShort fragmentsCytoskeletonMicrotubule massObserved exponential increaseEnzymeRemodelersFidgetinKataninCiliogenesis