Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules
Kuo YW, Trottier O, Mahamdeh M, Howard J. Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 5533-5541. PMID: 30837315, PMCID: PMC6431158, DOI: 10.1073/pnas.1818824116.Peer-Reviewed Original ResearchConceptsDual-function enzymeMicrotubule dynamicsMass of microtubulesMicrotubule cytoskeletonDynamic cellular processesCellular processesMicrotubule regrowthNeuronal morphogenesisSevering activityVivo phenotypeMicrotubule assaysMicrotubulesNumber of microtubulesSpastinMicrotubule fragmentsRescue frequencyShort fragmentsCytoskeletonMicrotubule massObserved exponential increaseEnzymeRemodelersFidgetinKataninCiliogenesis