Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes
Chen T, Coca S, Thiessen-Philbrook H, Heerspink H, Obeid W, Ix J, Fried L, Bonventre J, El-Khoury J, Shlipak M, Parikh C. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes. American Journal Of Nephrology 2022, 53: 775-785. PMID: 36630924, PMCID: PMC10006337, DOI: 10.1159/000528918.Peer-Reviewed Original ResearchConceptsKidney function declineEnd-stage kidney diseaseFunction declineMCP-1Tubular healthUrinary biomarkersEGFR declineKIM-1YKL-40High riskChronic kidney disease progressionSubsequent eGFR declineKidney disease progressionGlomerular filtration rateYKL-40 levelsAvailable urine samplesOne-year changeHigher baseline levelsSubset of participantsBaseline UACRMedian UACRCause mortalityUrine albuminTubular injuryCreatinine ratio