1993
Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs.
Gilliam AC, Steitz JA. Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 6781-6785. PMID: 8341699, PMCID: PMC47016, DOI: 10.1073/pnas.90.14.6781.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoprotein particleTrimethylguanosine capLow-abundance membersSmall nuclear RNASmall nuclear ribonucleoproteinNuclear ribonucleoprotein particleGlycerol gradient fractionsU RNAU11 small nuclear ribonucleoproteinsSnRNP complexTargeted degradationNuclear RNANuclear ribonucleoproteinRibonucleoprotein particleNuclear extractsSm classProtein componentsHeLa cellsRNPGradient fractionsRNAProteinScleroderma seraRibonucleoproteinCosediments
1983
Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome
Wolin S, Steitz J. Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome. Cell 1983, 32: 735-744. PMID: 6187471, DOI: 10.1016/0092-8674(83)90059-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigensAutoantigensBase SequenceDNAHumansMiceNucleic Acid ConformationRibonucleoproteinsRNARNA Polymerase IIIRNA, Small CytoplasmicConceptsHuman genomeRo RNAsSecondary structure homologyRNA polymerase IIISmall cytoplasmic ribonucleoproteinsClass III genesGenomic clonesMammalian cellsPolymerase IIIRNA componentStructure homologySingle copyCytoplasmic ribonucleoproteinHY5 RNAMouse cellsHuman cellsHY1Cell extractsGenesRNAGenomeRNAsHY3CellsMY1
1982
New directions in antinuclear antibody research: the Sm, RNP, Ro, and La antigens are found on small-RNA protein particles.
Hardin JA, Lerner MR, Lerner EA, Steitz JA. New directions in antinuclear antibody research: the Sm, RNP, Ro, and La antigens are found on small-RNA protein particles. American Journal Of Kidney Diseases 1982, 2: 98-100. PMID: 6179414.Peer-Reviewed Original ResearchDeciphering the mysteries of RNA‐containing lupus antigens
Lerner E, Lerner M, Hardin J, Janeway C, Steitz J. Deciphering the mysteries of RNA‐containing lupus antigens. Arthritis & Rheumatism 1982, 25: 761-766. PMID: 6179522, DOI: 10.1002/art.1780250709.Peer-Reviewed Original ResearchAntibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.
Hardin JA, Rahn DR, Shen C, Lerner MR, Wolin SL, Rosa MD, Steitz JA. Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles. Journal Of Clinical Investigation 1982, 70: 141-147. PMID: 6806318, PMCID: PMC370236, DOI: 10.1172/jci110587.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusRheumatoid arthritisPatient seraHepatitis B virus infectionB virus infectionPositive antinuclear antibodyRheumatic disease patientsJuvenile rheumatoid arthritisConnective tissue diseaseAntinuclear antibodiesSjögren's syndromeTissue diseaseDisease patientsAntigenic interrelationshipsSpecific subsetVirus infectionPatientsSuch seraMonoclonal immunoglobulin GImmunoglobulin GSerumAntibodiesAntigenic determinantsErythematosus
1979
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
Lerner M, Steitz J. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1979, 76: 5495-5499. PMID: 316537, PMCID: PMC411675, DOI: 10.1073/pnas.76.11.5495.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntinuclearAntibody SpecificityHumansLupus Erythematosus, SystemicMolecular WeightNucleoproteinsRibonucleoproteinsRNAConceptsSmall nuclear RNA moleculesNuclear extractsMouse Ehrlich ascites cellsSmall nuclear RNANuclear RNA moleculesSmall nuclear ribonucleoproteinNuclear RNP particlesMammalian nucleiVertebrate speciesNuclear RNANuclear ribonucleoproteinRNA moleculesSystemic lupus erythematosusDifferent polypeptidesEhrlich ascites cellsIdentical complementSpecific proteinsMajor polypeptidesRNP particlesMolecular identityPossible functionsNuclear processesNuclear RNPAnti-Sm seraVirtue of association