Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells
Cook HL, Lytle JR, Mischo HE, Li MJ, Rossi JJ, Silva DP, Desrosiers RC, Steitz JA. Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells. Current Biology 2005, 15: 974-979. PMID: 15916956, DOI: 10.1016/j.cub.2005.04.034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmBase PairingBlotting, NorthernBlotting, WesternCallithrixCD52 AntigenCell Line, TumorFlow CytometryGenetic VectorsGenome, ViralGlycoproteinsHerpesvirus 2, SaimiriineLentivirusLymphocyte ActivationMembrane ProteinsMicroarray AnalysisOncogene Proteins, ViralReceptors, Antigen, T-CellReceptors, ImmunologicRNA, Small NuclearT-LymphocytesTransduction, GeneticUp-RegulationConceptsSmall nuclear RNAHSURs 1Herpesvirus saimiriNuclear RNAExpression of genesAggressive T-cell leukemiaMarmoset T cellsHSUR 1U RNAAbundant viral transcriptCell activationT cellsHost mRNAsUnexpected roleIntracellular proteinsNorthern analysisSm classHost targetsViral transcriptsT cell activationNew World primatesRNAT-cell receptor betaT-cell leukemiaGamma chain