2002
The Divergent U12-Type Spliceosome Is Required for Pre-mRNA Splicing and Is Essential for Development in Drosophila
Otake LR, Scamborova P, Hashimoto C, Steitz JA. The Divergent U12-Type Spliceosome Is Required for Pre-mRNA Splicing and Is Essential for Development in Drosophila. Molecular Cell 2002, 9: 439-446. PMID: 11864616, DOI: 10.1016/s1097-2765(02)00441-0.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsAnimals, Genetically ModifiedBase SequenceDrosophila melanogasterDrosophila ProteinsGenes, LethalIntronsLarvaMolecular Sequence DataMutagenesis, InsertionalNerve Tissue ProteinsNuclear ProteinsNucleic Acid ConformationProtein IsoformsRibonucleoprotein, U4-U6 Small NuclearRibonucleoproteins, Small NuclearRNA PrecursorsRNA SplicingRNA, Small NuclearSequence AlignmentSequence Homology, Nucleic AcidSpliceosomesTranscription FactorsTransgenesConceptsU12-type spliceosomeThird instar larvalU12-type intronsPre-mRNA splicingU4atac/U6atacMetazoan organismsHomeodomain proteinsU5 snRNPsDrosophila melanogasterU12 spliceosomeMRNA intronsU12 snRNASingle locusU6atacInstar larvalSpliceosomeEmbryonic stagesCNS developmentIntronsMinor classU12DrosophilaMelanogasterVertebratesSnRNPs
1996
A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus
Tycowski K, Smith C, Shu M, Steitz J. A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14480-14485. PMID: 8962077, PMCID: PMC26158, DOI: 10.1073/pnas.93.25.14480.Peer-Reviewed Original ResearchConceptsSmall nucleolar RNA (snoRNA) speciesSite-specific ribose methylationXenopus oocyte systemSnoRNA speciesSnoRNA genesRibose methylationVertebrate cellsRNA speciesMultiple homologsSnoRNA stabilityRRNASnoRNAsOocyte systemRNA requirementsXenopusXenopus oocytesFibrillarinMethylationSpeciesOocytesVertebratesHomologCloningGenesTranscripts