2017
An Exportin-1–dependent microRNA biogenesis pathway during human cell quiescence
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D. An Exportin-1–dependent microRNA biogenesis pathway during human cell quiescence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e4961-e4970. PMID: 28584122, PMCID: PMC5488920, DOI: 10.1073/pnas.1618732114.Peer-Reviewed Original ResearchConceptsBiogenesis pathwayExportin 1Exportin-5Canonical miRNA biogenesis pathwayCanonical miRNA biogenesisTrimethylguanosine synthase 1MicroRNA biogenesis pathwayMiRNA biogenesis pathwayMiRNA processing pathwayStem cell biologyCellular growth arrestGroup of miRNAsExpression of miRNAsPrimary human fibroblastsMiRNA biogenesisPrimary miRNAsCellular quiescenceTissue homeostasisCell biologyProliferative arrestSpecific miRNAsCell quiescenceGrowth arrestBiogenesisMiRNAs
2010
miR-29 and miR-30 regulate B-Myb expression during cellular senescence
Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D. miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 108: 522-527. PMID: 21187425, PMCID: PMC3021067, DOI: 10.1073/pnas.1017346108.Peer-Reviewed Original ResearchConceptsB-myb expressionCellular senescenceMiR-30MiR-29Reporter constructsEndogenous B-MybMajor tumor suppressor mechanismTumor suppressor mechanismIrreversible growth arrestMicroRNA familiesMutant 3'UTRCellular DNA synthesisB-MybReplicative senescenceCompensatory mutationsGrowth arrestMutant sitesRb pathwaySenescenceSuppressor mechanismDNA synthesisRepressionInhibits senescenceExpressionMutations