2022
Morphological alteration of the pancreatic islet in ovariectomized rats fed a high-fat high-fructose diet
Chansela P, Potip B, Weerachayaphorn J, Kangwanrangsan N, Chukijrungroat N, Saengsirisuwan V. Morphological alteration of the pancreatic islet in ovariectomized rats fed a high-fat high-fructose diet. Histochemistry And Cell Biology 2022, 157: 427-442. PMID: 35037128, DOI: 10.1007/s00418-021-02062-0.Peer-Reviewed Original ResearchConceptsHigh-fat high-fructose dietHigh-fructose dietEstrogen deficiencyInsulin resistancePancreatic isletsOVX ratsWhole-body insulin resistanceExcessive caloric intakeElevated plasma glucoseInsulin-resistant statesΒ-cell dysfunctionInsulin-producing β-cellsDiabetes coexistsEstrogen replacementInsulin levelsOvariectomized ratsDiabetic statePlasma glucoseDisease progressionHistological changesPancreatic morphologyCaloric intakeFat accumulationGlucagon-producing α-cellsImmunohistochemical staining
2018
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor
Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell‐Richards K, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J. Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor. Hepatology 2018, 67: 560-574. PMID: 29023819, PMCID: PMC5893412, DOI: 10.1002/hep.29588.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseImpaired liver regenerationNonalcoholic steatohepatitisLiver regenerationHuh7 cellsLiver diseaseEffect of NAFLDPrevalent liver diseaseFatty liver diseaseC-JunHigh-fructose dietLiver biopsy specimensCell proliferationCalcium signalingHepG2 cellsLiver of ratsCell nuclear antigenCalcium release channelSimple steatosisLiver biopsyFatty liverTrisphosphate receptorBiopsy specimensRat modelType II inositol